PMID- 20377625
OWN - NLM
STAT- MEDLINE
DCOM- 20100707
LR  - 20211020
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 31
IP  - 6
DP  - 2010 Mar
TI  - Responses to cholecystokinin in the ventromedial nucleus of the rat hypothalamus 
      in vivo.
PG  - 1127-35
LID - 10.1111/j.1460-9568.2010.07144.x [doi]
AB  - The peptide cholecystokinin (CCK) is a short-term satiety signal released from 
      the gastrointestinal tract during food intake. From the periphery, CCK signalling 
      travels via the vagus nerve to reach the brainstem from which it is relayed 
      higher into the brain. The hypothalamus is a key integrator of appetite-related 
      stimuli and the ventromedial nucleus of the hypothalamus (VMN) is thought to have 
      an important role in the regulation of satiety. We investigated the effect of 
      intravenous injections of CCK on the spontaneous firing activity of single VMN 
      neurons in urethane-anaesthetised rats in vivo. We found that the predominant 
      effect of CCK on the electrical activity in the VMN is inhibitory. We analysed 
      the responses to CCK according to electrophysiologically distinct subpopulations 
      of VMN neurons and found that four of these VMN subpopulations were inhibited by 
      CCK, while five were not significantly affected. Finally, CCK-induced inhibitory 
      response in VMN neurons was not altered by pre-administration of intravenous 
      leptin.
FAU - Sabatier, Nancy
AU  - Sabatier N
AD  - Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson 
      Building, George Square, Edinburgh EH8 9XD, UK.
FAU - Leng, Gareth
AU  - Leng G
LA  - eng
GR  - BB/E015123/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Cholagogues and Choleretics)
RN  - 0 (Leptin)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Cholagogues and Choleretics/*pharmacology
MH  - Cholecystokinin/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - Leptin/pharmacology
MH  - Male
MH  - Neural Inhibition/drug effects
MH  - Neurons/classification/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ventromedial Hypothalamic Nucleus/cytology/*drug effects
EDAT- 2010/04/10 06:00
MHDA- 2010/07/08 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/07/08 06:00 [medline]
AID - EJN7144 [pii]
AID - 10.1111/j.1460-9568.2010.07144.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2010 Mar;31(6):1127-35. doi: 10.1111/j.1460-9568.2010.07144.x.