PMID- 20378181
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20220316
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 177
IP  - 1-2
DP  - 2010 May 15
TI  - Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical 
      global impression in chronic schizophrenia.
PG  - 32-6
LID - 10.1016/j.psychres.2009.01.014 [doi]
AB  - We conducted a randomized, sham-controlled repetitive transcranial magnetic 
      stimulation (rTMS) study in chronic schizophrenia in-patients (n=35) to evaluate 
      the therapeutic efficacy of 10 Hz stimulation. Patients, who were on stable 
      antipsychotic treatment, were randomly assigned to the active or sham condition. 
      In the active rTMS group, ten sessions with a total of 10,000 stimuli were 
      applied over the left dorsolateral prefrontal cortex at 110% of motor threshold. 
      The sham group received corresponding sham stimulation. Clinical improvement was 
      measured by the Clinical Global Impression scale (primary outcome measure), the 
      Global Assessment of Functioning Scale (GAF) and the Positive and Negative 
      Symptom Scale (PANSS; secondary outcome measures). Between-group comparisons 
      revealed no significant differences in clinical outcome variables. Only a 
      subgroup of patients with pronounced negative symptoms developed some clinical 
      improvement as indicated by significant changes in the GAF-scale. Besides there 
      is some evidence for a more favourable clinical outcome within this subgroup 
      after rTMS in the CGI-S and PANSS negative scale, too. In line with earlier 
      investigations, our results suggest a moderate - potentially clinically relevant 
      - treatment effect of prefrontal 10 Hz rTMS stimulation in chronic patients. 
      However, in our study this beneficial effect was restricted to subjects with 
      pronounced negative symptoms. CLINICAL TRIAL REGISTRATION INFORMATION: 
      ClinicalTrial.gov Identifier: NCT00169689, http://www.clinicaltrials.gov.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Cordes, Joachim
AU  - Cordes J
AD  - Department of Psychiatry and Psychotherapy, Heinrich-Heine University of 
      Dusseldorf, Bergische Landstr. 2, D-40629 Dusseldorf, Germany. 
      joachim@cordes@lvr.de
FAU - Thunker, Johanna
AU  - Thunker J
FAU - Agelink, Marcus W
AU  - Agelink MW
FAU - Arends, Mareke
AU  - Arends M
FAU - Mobascher, Arian
AU  - Mobascher A
FAU - Wobrock, Thomas
AU  - Wobrock T
FAU - Schneider-Axmann, Thomas
AU  - Schneider-Axmann T
FAU - Brinkmeyer, Jurgen
AU  - Brinkmeyer J
FAU - Mittrach, Margarethe
AU  - Mittrach M
FAU - Regenbrecht, Gunnar
AU  - Regenbrecht G
FAU - Wolwer, Wolfgang
AU  - Wolwer W
FAU - Winterer, Georg
AU  - Winterer G
FAU - Gaebel, Wolfgang
AU  - Gaebel W
LA  - eng
SI  - ClinicalTrials.gov/NCT00169689
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100408
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Outcome Assessment, Health Care/methods
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*physiopathology/*therapy
MH  - *Schizophrenic Psychology
MH  - Statistics as Topic
MH  - Transcranial Magnetic Stimulation/*methods
EDAT- 2010/04/10 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/04/10 06:00
PHST- 2008/06/15 00:00 [received]
PHST- 2009/01/03 00:00 [revised]
PHST- 2009/01/07 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S0165-1781(09)00024-9 [pii]
AID - 10.1016/j.psychres.2009.01.014 [doi]
PST - ppublish
SO  - Psychiatry Res. 2010 May 15;177(1-2):32-6. doi: 10.1016/j.psychres.2009.01.014. 
      Epub 2010 Apr 8.