PMID- 20378403
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20221207
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 11
IP  - 5
DP  - 2010 May
TI  - Olfactory dysfunction in idiopathic REM sleep behavior disorder.
PG  - 458-61
LID - 10.1016/j.sleep.2009.09.013 [doi]
AB  - BACKGROUND: Olfactory dysfunction is frequently observed in patients with 
      idiopathic REM sleep behavior disorder (iRBD) such as Parkinson's disease or 
      dementia with Lewy bodies. METHODS: Olfactory function tests using Sniffin' 
      Sticks and Odor Stick Identification Test for Japanese (OSIT-J) were performed in 
      73 consecutive middle-aged (range, 50-69 years) patients with iRBD, 33 
      consecutive older-aged (71-82 years) patients with iRBD, and 28 control subjects 
      (55-70 years). RESULTS: Odor identification was more frequently impaired than 
      odor threshold or discrimination among the iRBD group and allowed better 
      discrimination between the middle-aged iRBD group and age-adjusted control 
      subjects. The area under the curve for threshold, discrimination, identification, 
      TDI score and OSIT-J score determined from receiver operating characteristic 
      curves were 0.831 (0.753-0.909), 0.761 (0.666-0.855), 0.938 (0.894-0.982), 0.939 
      (0.897-0.981), and 0.965 (0.931-0.999), respectively. Discrimination and 
      identification scores were significantly lower in the older-aged iRBD group than 
      in the middle-aged iRBD group. A significant correlation was observed between the 
      identification score on Sniffin' Sticks and OSIT-J score (r=0.5910, P<0.0001, 
      n=106, Spearman's rank). CONCLUSION: Anosmia/hyposmia may be a feature of iRBD. 
      Olfactory dysfunction in iRBD is a consistent, widespread central nervous 
      abnormality of different olfactory modalities with different cognitive 
      complexity.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Miyamoto, Tomoyuki
AU  - Miyamoto T
AD  - Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University 
      School of Medicine, Tochigi 321-0293, Japan. miyatomo@dokkyomed.ac.jp
FAU - Miyamoto, Masayuki
AU  - Miyamoto M
FAU - Iwanami, Masaoki
AU  - Iwanami M
FAU - Hirata, Koichi
AU  - Hirata K
FAU - Kobayashi, Mina
AU  - Kobayashi M
FAU - Nakamura, Masaki
AU  - Nakamura M
FAU - Inoue, Yuichi
AU  - Inoue Y
LA  - eng
PT  - Journal Article
DEP - 20100407
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Asian People
MH  - Discrimination, Psychological
MH  - Female
MH  - Humans
MH  - Lewy Body Disease/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Olfaction Disorders/*diagnosis/*epidemiology
MH  - Parkinson Disease/epidemiology
MH  - Polysomnography
MH  - REM Sleep Behavior Disorder/diagnosis/*epidemiology
MH  - Sensory Thresholds
MH  - *Smell
EDAT- 2010/04/10 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/10 06:00
PHST- 2009/07/25 00:00 [received]
PHST- 2009/09/12 00:00 [revised]
PHST- 2009/09/21 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - S1389-9457(10)00098-5 [pii]
AID - 10.1016/j.sleep.2009.09.013 [doi]
PST - ppublish
SO  - Sleep Med. 2010 May;11(5):458-61. doi: 10.1016/j.sleep.2009.09.013. Epub 2010 Apr 
      7.