PMID- 20379390
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2010
DP  - 2010
TI  - Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of 
      dendritic cells and tumor cells.
PG  - 752381
LID - 10.1155/2010/752381 [doi]
LID - 752381
AB  - The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes 
      (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent 
      antigen-presenting cells and play a central role in the initiation and regulation 
      of primary immune responses. Thus, DCs-based vaccination represents a potentially 
      powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and 
      whole tumor cells represent an alternative approach to deliver, process, and 
      subsequently present a broad spectrum of antigens, including those known and 
      unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions 
      have been infused back into patient, they migrate to secondary lymphoid organs, 
      where the generation of antigen-specific polyclonal CTL responses occurs. We will 
      discuss perspectives for future development of DCs/tumor fusions for CTL 
      induction.
FAU - Koido, Shigeo
AU  - Koido S
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, The 
      Jikei University School of Medicine, Tokyo 105-8461, Japan. 
      shigeo_koido@jikei.ac.jp
FAU - Homma, Sadamu
AU  - Homma S
FAU - Hara, Eiichi
AU  - Hara E
FAU - Namiki, Yoshihisa
AU  - Namiki Y
FAU - Ohkusa, Toshifumi
AU  - Ohkusa T
FAU - Gong, Jianlin
AU  - Gong J
FAU - Tajiri, Hisao
AU  - Tajiri H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100407
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Animals
MH  - *Cell Fusion
MH  - Clinical Trials as Topic
MH  - Dendritic Cells/*pathology
MH  - Epitopes/*immunology
MH  - Histocompatibility Antigens/immunology
MH  - Humans
MH  - Lymphocyte Activation/*immunology
MH  - Models, Animal
MH  - Neoplasms/immunology/*pathology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
PMC - PMC2850552
EDAT- 2010/04/10 06:00
MHDA- 2010/09/14 06:00
PMCR- 2010/04/07
CRDT- 2010/04/10 06:00
PHST- 2009/11/29 00:00 [received]
PHST- 2010/01/21 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PHST- 2010/04/07 00:00 [pmc-release]
AID - 10.1155/2010/752381 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2010;2010:752381. doi: 10.1155/2010/752381. Epub 2010 Apr 7.