PMID- 20381357
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220330
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Jun
TI  - The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid 
      haemorrhage model.
PG  - 770-3
LID - 10.1016/j.jocn.2009.10.012 [doi]
AB  - We investigated the effect of two different doses of dexmedetomidine on vasospasm 
      in a rat model of subarachnoid haemorrhage (SAH). SAH was induced by injecting 
      0.3 mL blood into the cisterna magna in all rat groups except the control (Group 
      C). At 1 hour and 24 hours after SAH, 5 microg/kg dexmedetomidine was given to 
      group D5, and 10 microg/kg dexmedetomidine was given to group D10. No medication 
      was administered to the haemorrhage group (Group H). Malondialdehyde (MDA) and 
      paraoxonase (PON) levels were measured at 48 hours after SAH. Mean wall thickness 
      (MWT), mean luminal diameter (MLD), and proliferating cell nuclear antigen (PCNA) 
      expression of the basilar artery were evaluated. MDA levels and MWT were lower in 
      the dexmedetomidine groups. The lowest MDA levels and MWT were found in Group 
      D10. The MLD was lowest in Group H. PCNA expression was observed only in Group 
      D10. We concluded that dexmedetomidine reduces oxidative stress and vasospasm 
      following SAH in a dose-dependent manner.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Ayoglu, Hilal
AU  - Ayoglu H
AD  - Department of Anesthesiology and Reanimation, School of Medicine, Zonguldak 
      Karaelmas University, Kozlu, Zonguldak 67600, Turkey. periayogluzku@yahoo.com
FAU - Gul, Sanser
AU  - Gul S
FAU - Hanci, Volkan
AU  - Hanci V
FAU - Bahadir, Burak
AU  - Bahadir B
FAU - Bektas, Sibel
AU  - Bektas S
FAU - Mungan, Ayca Gorkem
AU  - Mungan AG
FAU - Turan, Isil Ozkocak
AU  - Turan IO
FAU - Acikgoz, Bektas
AU  - Acikgoz B
LA  - eng
PT  - Journal Article
DEP - 20100408
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 67VB76HONO (Dexmedetomidine)
SB  - IM
MH  - Analgesics, Non-Narcotic/*therapeutic use
MH  - Animals
MH  - Dexmedetomidine/*therapeutic use
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Pons/drug effects/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Subarachnoid Hemorrhage/*complications
MH  - Vasospasm, Intracranial/*drug therapy/*etiology
EDAT- 2010/04/13 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/13 06:00
PHST- 2009/08/09 00:00 [received]
PHST- 2009/10/13 00:00 [revised]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - S0967-5868(09)00731-0 [pii]
AID - 10.1016/j.jocn.2009.10.012 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Jun;17(6):770-3. doi: 10.1016/j.jocn.2009.10.012. Epub 2010 
      Apr 8.