PMID- 20381392
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20220410
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 100
IP  - 3
DP  - 2010 Jul
TI  - Apolipoprotein E polymorphisms and type 2 diabetes: a meta-analysis of 30 studies 
      including 5423 cases and 8197 controls.
PG  - 283-91
LID - 10.1016/j.ymgme.2010.03.008 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a highly complicated metabolic disorder for 
      which there is worldwide effort for the identification of susceptibility genes. 
      Polymorphisms of the Apolipoprotein E (ApoE) gene are associated with plasma 
      lipid and lipoprotein levels and influence cardiovascular risk. Since insulin 
      resistance is known to be strongly associated with metabolic dyslipidemia, ApoE 
      polymorphisms have been implicated in predisposition to diabetes but the results 
      of the individual studies were inconclusive. We present here a meta-analysis of 
      population-based case-control genetic-association studies relating ApoE 
      polymorphisms and T2DM. We included in the analysis 30 studies, which reported 
      data of ApoE genotypes in 5423 T2DM patients and 8197 healthy unrelated controls. 
      Multivariate and univariate methods suggest a significant role played by the E2 
      allele, since carriers of the E2 allele were at elevated risk for T2DM (Odds 
      Ratio=1.18, 95% CI: 1.02, 1.35). There was no evidence for publication bias or 
      other small-study related bias or significant heterogeneity in the analyses. 
      Cumulative meta-analysis revealed no trend of the effect estimates over time and 
      influential analysis excluded the possibility of a single influential study. E2 
      allele of ApoE seems to be a moderate risk factor for T2DM. Meta-regression 
      analysis provided some weak evidence that the risk conferred by E2 allele is 
      mediated through altering serum lipid levels (Total Cholesterol, LDL and HDL). 
      Further studies are needed in order to elucidate the metabolic mechanism of this 
      association as well as to study its effects on larger populations.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Anthopoulos, P G
AU  - Anthopoulos PG
AD  - Department of Cell Biology and Biophysics, Faculty of Biology, University of 
      Athens, Greece. pbagos@ucg.gr
FAU - Hamodrakas, S J
AU  - Hamodrakas SJ
FAU - Bagos, P G
AU  - Bagos PG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20100319
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
RN  - 0 (Apolipoprotein E2)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Lipids)
SB  - IM
MH  - Alleles
MH  - Apolipoprotein E2/genetics
MH  - Apolipoproteins E/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Lipids/blood
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2010/04/13 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/03/13 00:00 [received]
PHST- 2010/03/14 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - S1096-7192(10)00099-5 [pii]
AID - 10.1016/j.ymgme.2010.03.008 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2010 Jul;100(3):283-91. doi: 10.1016/j.ymgme.2010.03.008. Epub 
      2010 Mar 19.