PMID- 20382109
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20220409
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 395
IP  - 4
DP  - 2010 May 14
TI  - Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells 
      and atherosclerogenesis independent of LDL cholesterol level.
PG  - 477-83
LID - 10.1016/j.bbrc.2010.04.031 [doi]
AB  - Epidemiological studies suggest that insulin resistance is an independent risk 
      factor for cardiovascular disease. However, there is little information on the 
      role of insulin resistance in atherosclerogenesis independent of LDL cholesterol 
      level. The aim of this study was to investigate the impact of systemic insulin 
      resistance on monocyte adhesion to endothelial cells and atherosclerotic lesions 
      independent of LDL cholesterol level. KKAy mice are obese mice with spontaneous 
      diabetes and insulin resistance, and normal levels of LDL cholesterol. In 
      parallel with systemic insulin resistance, decreased insulin signal, and the 
      increased expression of monocyte chemoattractant protein-1 (MCP-1) were noted in 
      macrophages isolated from KKAy mice. These mice showed enhanced monocyte adhesion 
      to the endothelial cells of the thoracic artery. Furthermore, these mice showed 
      expanded atherosclerotic lesions when fed high cholesterol diet. Our data 
      indicate that insulin resistance promotes the atherosclerogenesis independent of 
      LDL cholesterol level. Decreased insulin signaling in macrophages associated with 
      systemic insulin resistance could be involved, at least in part, in this 
      pathological process.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Mita, Tomoya
AU  - Mita T
AD  - Department of Medicine, Metabolism and Endocrinology, Juntendo University 
      Graduate School of Medicine, Tokyo 113-8421, Japan.
FAU - Goto, Hiromasa
AU  - Goto H
FAU - Azuma, Kosuke
AU  - Azuma K
FAU - Jin, Wen Long
AU  - Jin WL
FAU - Nomiyama, Takashi
AU  - Nomiyama T
FAU - Fujitani, Yoshio
AU  - Fujitani Y
FAU - Hirose, Takahisa
AU  - Hirose T
FAU - Kawamori, Ryuzo
AU  - Kawamori R
FAU - Watada, Hirotaka
AU  - Watada H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100409
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/metabolism/*pathology
MH  - Cell Adhesion
MH  - Chemokine CCL2/metabolism
MH  - Cholesterol, LDL/blood/metabolism
MH  - Diet
MH  - Endothelial Cells/physiology
MH  - Endothelium, Vascular/*physiology
MH  - Female
MH  - *Insulin Resistance
MH  - Macrophages/physiology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Monocytes/*pathology/physiology
EDAT- 2010/04/13 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/04/05 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S0006-291X(10)00693-5 [pii]
AID - 10.1016/j.bbrc.2010.04.031 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2010 May 14;395(4):477-83. doi: 
      10.1016/j.bbrc.2010.04.031. Epub 2010 Apr 9.