PMID- 20382412 OWN - NLM STAT- MEDLINE DCOM- 20100922 LR - 20100614 IS - 1879-2472 (Electronic) IS - 0049-3848 (Linking) VI - 126 IP - 1 DP - 2010 Jul TI - Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention. PG - 56-60 LID - 10.1016/j.thromres.2010.03.001 [doi] AB - INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha