PMID- 20382583
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100412
IS  - 1499-3872 (Print)
VI  - 9
IP  - 2
DP  - 2010 Apr
TI  - Impact of human leukocyte antigen matching on hepatitis B virus recurrence after 
      liver transplantation.
PG  - 139-43
AB  - BACKGROUND: Liver transplantation (LT) is an effective therapy for end-stage 
      hepatitis B virus (HBV) infection. Recurrence of HBV is one of the frequent 
      complications. In the present study, we investigated whether human leukocyte 
      antigen (HLA) matching influences the incidence of HBV recurrence, and the time 
      point of HBV recurrence after LT. METHODS: One hundred and two recipients of LT 
      with end-stage chronic HBV infection were reviewed. The triple-drug 
      immunosuppression regimen consisted of tacrolimus, mycophenolate, and prednisone. 
      All patients were subjected to prophylaxis with hepatitis B immunoglobulin and 
      lamivudine. HLA typing was performed using a sequence-specific primer-polymerase 
      chain reaction kit. Serology for hepatitis B and HBV DNA was examined using a 
      commercial kit. RESULTS: The incidence of recurrent HBV infection post-LT was 
      6.86%. The recurrent infection of HBV was independent of the degree of HLA 
      matching (P>0.05). The time point of HBV recurrence, however, was prolonged in 
      HLA-A matched patients compared with matchless patients (P=0.049). The recurrence 
      of HBV infection was independent of HLA compatibility. CONCLUSIONS: This 
      retrospective analysis showed that more HLA-A locus compatibility is associated 
      with a prolonged time of recurrence of HBV in patients after LT for end-stage HBV 
      infection. The incidence of HBV recurrence is independent of HLA compatibility.
FAU - Zhao, Hong
AU  - Zhao H
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First 
      Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, 
      China.
FAU - Hu, Jian-Hua
AU  - Hu JH
FAU - Zhou, Lin
AU  - Zhou L
FAU - Xu, Xiao
AU  - Xu X
FAU - Wu, Jian
AU  - Wu J
FAU - Meng, Xue-Qin
AU  - Meng XQ
FAU - Fan, Jun
AU  - Fan J
FAU - Ma, Wei-Hang
AU  - Ma WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - DNA, Viral/analysis
MH  - Female
MH  - Hepatitis B/*etiology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Liver Transplantation/*adverse effects/immunology
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
EDAT- 2010/04/13 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 1336 [pii]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2010 Apr;9(2):139-43.