PMID- 20383039
OWN - NLM
STAT- MEDLINE
DCOM- 20100707
LR  - 20190727
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 220
IP  - 4
DP  - 2010 Apr
TI  - Fragmented QRS is predictive of myocardial dysfunction, pulmonary hypertension 
      and severity in mitral stenosis.
PG  - 279-83
AB  - Reliable non-invasive new indices reflecting severity of rheumatic valve disease 
      would be highly beneficial. Recently, presence of fragmented QRS (fQRS) in ECG 
      was accepted as a marker of myocardial fibrosis. fQRS is defined as the presence 
      of RSR' patterns such as additional R wave (R'), notching in the R wave or the S 
      wave in 2 contiguous leads. Purpose of our study was to establish frequency of 
      fQRS in isolated rheumatic mitral stenosis compared with control group. We 
      studied 193 patients with mitral stenosis and age/gender matched 97 healthy 
      subjects. Patients were categorized according to the New York Heart Association 
      (NYHA) functional class. Severity of mitral stenosis, left ventricular ejection 
      fraction, and pulmonary artery pressure were obtained by means of 
      echocardiography. fQRS was defined on routine 12-lead ECG. fQRS was more frequent 
      in subjects with mitral stenosis than in control group (p < 0.001). fQRS was 
      associated with low ejection fraction, pulmonary hypertension, poor functional 
      NYHA class, increased mean mitral valve gradient and decreased mitral valve area 
      (R = 0.1, p = 0.02; R = 0.1, p = 0.001; R = 0.1, p = 0.01; R = 0.1, p = 0.04; and 
      R = -0.1, p = 0.009, respectively). Mitral valve area was the only independent 
      predictor of fQRS in multiple logistic regression analysis. In conclusion, fQRS 
      is predictive of severe mitral stenosis, lower ejection fraction, increased 
      pulmonary artery pressure, and poor functional class. fQRS might be considered as 
      a novel indicator of mitral stenosis severity and associated complications.
FAU - Yuce, Murat
AU  - Yuce M
AD  - Cardiology Department, Gaziantep University, School of Medicine, Gaziantep, 
      Turkey.
FAU - Davutoglu, Vedat
AU  - Davutoglu V
FAU - Ozbala, Burcu
AU  - Ozbala B
FAU - Ercan, Suleyman
AU  - Ercan S
FAU - Kizilkan, Nese
AU  - Kizilkan N
FAU - Akcay, Murat
AU  - Akcay M
FAU - Sari, Ibrahim
AU  - Sari I
FAU - Akkoyun, Cayan
AU  - Akkoyun C
FAU - Dogan, Adnan
AU  - Dogan A
FAU - Alici, M Hayri
AU  - Alici MH
FAU - Yavuz, Fethi
AU  - Yavuz F
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
SB  - IM
MH  - *Echocardiography
MH  - Female
MH  - Heart/*physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/*etiology/physiopathology
MH  - Mitral Valve Stenosis/*complications/pathology/physiopathology
MH  - Myocardium/*pathology
MH  - Rheumatic Heart Disease/complications/pathology
EDAT- 2010/04/13 06:00
MHDA- 2010/07/08 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/08 06:00 [medline]
AID - JST.JSTAGE/tjem/220.279 [pii]
AID - 10.1620/tjem.220.279 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2010 Apr;220(4):279-83. doi: 10.1620/tjem.220.279.