PMID- 20383650
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20101028
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 47
IP  - 4
DP  - 2010 Dec
TI  - Joint and distinct risk factors associated with micro- and macrovascular 
      complications in a cohort of type 2 diabetic patients cared through disease 
      management.
PG  - 301-8
LID - 10.1007/s00592-010-0186-4 [doi]
AB  - We analysed the risk factors associated with diabetic complications in the cohort 
      of patients assisted by a type 2 diabetes mellitus (T2DM) shared-care program. We 
      analysed registry data from 16,136 T2DM patients. Of them, 4,781 had 
      microangiopathy, 3,469 CV events. They were 70.5 +/- 17.1 years old, 50% were male, 
      disease duration 13.3 +/- 7.8 years, BMI 28.7 +/- 4.9 kg/m(2), HbA1c 7.08 +/- 1.23%, FBG 
      134.7 +/- 35.7 mg/dl, 2hPPBG 163.9 +/- 47.8 mg/dl, 12.5% smokers. Cholesterol 202.5 +/- 
      37.6 mg/dl, HDL 51.4 +/- 20.4 mg/dl, LDL 126.5 +/- 36.0 mg/dl, triglyceride 146.2 +/- 
      72.4 mg/dl, SBP 137.8 +/- 14.2 mmHg, DBP 80.7 +/- 10.8 mmHg, 10-year CV risk score 
      13.7 +/- 9.1; 70.4% had no microangiopathy-i.e. renal, retinal, peripheral nerve 
      disease-and 78.5% of patients had no CV events. Age-adjusted risk factors 
      associated with diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and 
      triglyceride. FBG and SBP were associated with microangiopathy, whereas smoking 
      with cardiovascular events. Optimal targets were reached in: FBG 17%, 2hPPBG 8%, 
      HbA1c 21%, cholesterol 17%, HDL 8%, LDL 5%, triglyceride 20%, SBP 13%, DBP 30%. 
      Drug profiles showed 13% using metformin, 28% sulphonilureas, 26% bitherapy, 4% 
      insulin; 12% statins, 16% anti-platelets, 27% anti-hypertensives, 2% 
      anti-coagulants. T2DM patients showed an acceptable CV risk profile. Joint risk 
      factors for diabetic complications were male gender, HbA1c, 2hPPBG, HDL, and 
      triglyceride. Distinct risk factors were FBG and SBP for micro- and smoking for 
      macrovascular disease. A targeted-to-treat approach needs more attention in the 
      care of T2DM patients.
FAU - Ciardullo, Anna V
AU  - Ciardullo AV
AD  - Modena shared-care Diabetes Program, Local Health Unit, Azienda USL, Modena, 
      Italy. a.ciardullo@ausl.mo.it
FAU - Daghio, M Monica
AU  - Daghio MM
FAU - Bevini, Massimo
AU  - Bevini M
FAU - Feltri, Gaetano
AU  - Feltri G
FAU - Novi, Doriano
AU  - Novi D
FAU - Fattori, Giuseppe
AU  - Fattori G
FAU - Borsari, Silvana
AU  - Borsari S
FAU - Donato, Carlo Di
AU  - Donato CD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100410
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiovascular Diseases/epidemiology/prevention & control
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology/*therapy
MH  - Diabetic Angiopathies/epidemiology/*etiology/prevention & control
MH  - Disease Management
MH  - Female
MH  - Humans
MH  - Male
MH  - *Managed Care Programs
MH  - Middle Aged
MH  - Primary Prevention/methods/statistics & numerical data
MH  - Risk Factors
MH  - Secondary Prevention/methods/statistics & numerical data
EDAT- 2010/04/13 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/04/13 06:00
PHST- 2008/05/14 00:00 [received]
PHST- 2009/12/15 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1007/s00592-010-0186-4 [doi]
PST - ppublish
SO  - Acta Diabetol. 2010 Dec;47(4):301-8. doi: 10.1007/s00592-010-0186-4. Epub 2010 
      Apr 10.