PMID- 20384725
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20101102
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 51
IP  - 10
DP  - 2010 Oct
TI  - Can changes in cortical excitability distinguish progressive from juvenile 
      myoclonic epilepsy?
PG  - 2084-8
LID - 10.1111/j.1528-1167.2010.02557.x [doi]
AB  - PURPOSE: We used transcranial magnetic stimulation (TMS) to investigate whether 
      there were any characteristic cortical excitability changes in progressive 
      myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME). METHODS: 
      Six patients with PME were studied. Motor threshold (MT) at rest and recovery 
      curve analysis using paired-pulse stimulation at a number of interstimulus 
      intervals (ISIs) was determined. Results were compared to those of 9 patients 
      with chronic refractory JME and 10 with chronic well-controlled JME. RESULTS: PME 
      showed a marked increase in cortical excitability at all the long ISIs (p < 
      0.01), compared to refractory JME (effect sizes ranging from 1.4 to 1.9) and 
      well-controlled JME (effect sizes ranging from 2.0 to 2.4). Significant 
      differences at the short ISIs 2-5 ms were seen only on comparison with the 
      well-controlled group (p < 0.05, effect size 0.6, 0.7). There were no significant 
      differences in MTs of PME compared to either JME groups. CONCLUSION: Our findings 
      demonstrate specific differences in cortical excitability using TMS between PME 
      and those with JME, particularly at long latencies in the paired-pulse paradigm, 
      implicating a role for gamma-aminobutyric acid (GABA)(B) -mediated networks.
CI  - Wiley Periodicals, Inc. (c) 2010 International League Against Epilepsy.
FAU - Badawy, Radwa A B
AU  - Badawy RA
AD  - Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.
FAU - Macdonell, Richard A L
AU  - Macdonell RA
FAU - Jackson, Graeme D
AU  - Jackson GD
FAU - Berkovic, Samuel F
AU  - Berkovic SF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/therapeutic use
MH  - Cerebral Cortex/physiopathology
MH  - Chronic Disease
MH  - Diagnosis, Differential
MH  - Drug Resistance
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiopathology
MH  - Myoclonic Epilepsies, Progressive/*diagnosis/drug therapy/physiopathology
MH  - Myoclonic Epilepsy, Juvenile/*diagnosis/drug therapy/physiopathology
MH  - Transcranial Magnetic Stimulation/methods/*statistics & numerical data
MH  - Unverricht-Lundborg Syndrome/diagnosis/physiopathology
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2010/04/14 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
AID - EPI2557 [pii]
AID - 10.1111/j.1528-1167.2010.02557.x [doi]
PST - ppublish
SO  - Epilepsia. 2010 Oct;51(10):2084-8. doi: 10.1111/j.1528-1167.2010.02557.x.