PMID- 20385791
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20220321
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 115
IP  - 23
DP  - 2010 Jun 10
TI  - Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology.
PG  - 4820-3
LID - 10.1182/blood-2010-01-266775 [doi]
AB  - Genome-wide association and candidate gene studies implicate different genetic 
      variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma 
      (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen 
      (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of 
      non-Hispanic white descent from a US multicenter study. Allele-disease 
      associations were assessed by logistic regression for NHL and its subtypes. 
      Statistically significant associations between HLA and NHL subtypes include 
      HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), 
      HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and 
      HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed 
      significant heterozygote advantage for HLA class I alleles and NHL, and 
      particularly DLBCL (P trend = .01 for elevated risk with increasing number of 
      homozygous alleles). Our results support a role for HLA in the etiology of NHL 
      and its subtypes.
FAU - Wang, Sophia S
AU  - Wang SS
AD  - Division of Cancer Etiology, Department of Population Sciences, City of Hope, 
      Duarte, CA 91010, USA. sowang@coh.org
FAU - Abdou, Amr M
AU  - Abdou AM
FAU - Morton, Lindsay M
AU  - Morton LM
FAU - Thomas, Rasmi
AU  - Thomas R
FAU - Cerhan, James R
AU  - Cerhan JR
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Cozen, Wendy
AU  - Cozen W
FAU - Rothman, Nathaniel
AU  - Rothman N
FAU - Davis, Scott
AU  - Davis S
FAU - Severson, Richard K
AU  - Severson RK
FAU - Bernstein, Leslie
AU  - Bernstein L
FAU - Hartge, Patricia
AU  - Hartge P
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - N01 PC067010/PC/NCI NIH HHS/United States
GR  - N01 PC067008/PC/NCI NIH HHS/United States
GR  - N01-PC-67009/PC/NCI NIH HHS/United States
GR  - N01 PC065064/PC/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - N01 PC067009/CN/NCI NIH HHS/United States
GR  - N02-PC-71105/PC/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20100412
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Female
MH  - Genome-Wide Association Study
MH  - Heterozygote
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC2890176
EDAT- 2010/04/14 06:00
MHDA- 2010/07/20 06:00
PMCR- 2011/06/10
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
PHST- 2011/06/10 00:00 [pmc-release]
AID - S0006-4971(20)34901-6 [pii]
AID - 2010/266775 [pii]
AID - 10.1182/blood-2010-01-266775 [doi]
PST - ppublish
SO  - Blood. 2010 Jun 10;115(23):4820-3. doi: 10.1182/blood-2010-01-266775. Epub 2010 
      Apr 12.