PMID- 20386461
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20100526
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Jun
TI  - Marked improvement of psychotic symptoms after electroconvulsive therapy in 
      Parkinson disease.
PG  - 111-5
LID - 10.1097/YCT.0b013e3181c18a3d [doi]
AB  - OBJECTIVES: Psychosis is common and often medically intractable in Parkinson 
      disease (PD). Sometimes, its management is essential for the determination of the 
      prognosis of PD. There have been several lines of studies demonstrating the 
      effectiveness of electroconvulsive therapy (ECT) for depression in PD but very 
      few for psychosis. The purpose of this retrospective study was to examine the 
      effects of acute ECT on PD-associated psychosis. METHODS: The subjects were 5 
      elderly PD patients (duration, 2-10 years); 4 of whom were diagnosed as "other 
      substance (antiparkinsonian medications)-induced psychotic disorder, with 
      hallucinations," and as 1 "psychotic disorder due to PD, with hallucinations," 
      according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth 
      Edition, Text Revision. Two patients had comorbidity of major depressive 
      disorder, single episode. The psychosis, being refractory to antipsychotics, was 
      treated with a course of acute ECT. Psychiatric conditions were evaluated using 
      the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale 
      (HDRS), and the Global Assessment of Functioning (GAF) scale. Motor function was 
      assessed using the Hoehn and Yahr staging. RESULTS: The total BPRS and GAF scores 
      after ECT improved significantly compared with those just before ECT. The Hoehn 
      and Yahr staging also showed significant improvement. No marked adverse effects 
      were seen. Duration of the improvement was between 5 and 30 weeks in followed-up 
      patients. CONCLUSIONS: Acute ECT was effective for medically refractory psychosis 
      in patients with PD regardless of the comorbidity of depression. Our results 
      suggest a possible indication of acute ECT for refractory psychosis in patients 
      with PD.
FAU - Ueda, Satoshi
AU  - Ueda S
AD  - Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan. 
      sat333@nms.ac.jp
FAU - Koyama, Keiko
AU  - Koyama K
FAU - Okubo, Yoshiro
AU  - Okubo Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Parkinson Disease/complications/*therapy
MH  - Psychotic Disorders/complications/*therapy
MH  - Retrospective Studies
EDAT- 2010/04/14 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 10.1097/YCT.0b013e3181c18a3d [doi]
PST - ppublish
SO  - J ECT. 2010 Jun;26(2):111-5. doi: 10.1097/YCT.0b013e3181c18a3d.