PMID- 20387876
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20131121
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 44
IP  - 9
DP  - 2010 May 1
TI  - Hepatic CYP1A induction by chlorinated dioxins and related compounds in the 
      endangered black-footed albatross from the North Pacific.
PG  - 3559-65
LID - 10.1021/es1000177 [doi]
AB  - The present study assesses effects of dioxins and related compounds (DRCs) 
      including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and 
      dioxin-like polychlorinated biphenyls (DL-PCBs) on cytochrome P450 1A (CYP1A) 
      expression level in liver of black-footed albatrosses (Phoebastria nigripes) 
      collected from the North Pacific. Total 2,3,7,8-tetrachlorodibenzo-p-dioxin 
      (2,3,7,8-T(4)CDD) toxic equivalents (TEQs) derived from toxic equivalency factor 
      for birds proposed by World Health Organization were in the range of 2100 to 10 
      000 pg/g lipid wt (120-570 pg/g wet wt). Simultaneously, microsomal 
      alkoxyresorufin O-dealkylase (AROD) activities, including methoxy-, ethoxy-, 
      pentoxy-, and benzyloxy-resorufin O-dealkylase activities were also measured in 
      the same specimens. Total TEQs and TEQ (on wet wt basis) from some individual DRC 
      congeners had significant positive correlations with AROD activities, suggesting 
      induction of CYP1A by DRCs. Congeners like 2,3,7,8-T(4)CDD and most of the 
      DL-PCBs that showed no significant positive correlations between the 
      concentrations and AROD activities, exhibited significant negative correlations 
      between AROD activities and the concentration ratio of the congener to a 
      recalcitrant CB169, suggesting preferential metabolism of these congeners by 
      induced CYP1A. As far as we know, this is the first direct evidence revealing 
      that hepatic CYP1A level is elevated with the accumulation of DRCs in the wild 
      black-footed albatross population. The present study gives more robust estimate 
      of impacts of DRCs on CYP1A induction in this rare pelagic species than indexes 
      like hazard quotient and TEQ-threshold comparison that have been so far carried 
      out.
FAU - Kubota, Akira
AU  - Kubota A
AD  - Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho, 
      Matsuyama, Japan.
FAU - Watanabe, Mafumi
AU  - Watanabe M
FAU - Kunisue, Tatsuya
AU  - Kunisue T
FAU - Kim, Eun-Young
AU  - Kim EY
FAU - Tanabe, Shinsuke
AU  - Tanabe S
FAU - Iwata, Hisato
AU  - Iwata H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4R7X1O2820 (Chlorine)
RN  - 8U54U639VI (dibenzofuran)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - O1B5KJ235I (dibenzo(1,4)dioxin)
SB  - IM
MH  - Animals
MH  - Benzofurans/chemistry
MH  - Birds
MH  - Chlorine/*toxicity
MH  - Cytochrome P-450 CYP1A1/*biosynthesis
MH  - Dioxins/chemistry/*toxicity
MH  - Environmental Pollutants
MH  - Liver/drug effects/*metabolism
MH  - Microsomes, Liver/drug effects
MH  - Risk Assessment
MH  - Water Pollutants, Chemical/analysis
EDAT- 2010/04/15 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 10.1021/es1000177 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2010 May 1;44(9):3559-65. doi: 10.1021/es1000177.