PMID- 20388056
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 51
IP  - 7
DP  - 2010 Jul
TI  - Human leukocyte antigen class I alleles and the risk of chronic myelogenous 
      leukemia: a meta-analysis.
PG  - 1288-92
LID - 10.3109/10428191003802340 [doi]
AB  - A number of different human leukocyte antigen (HLA) allele associations with 
      chronic myelogenous leukemia (CML) have been previously reported. The specific 
      associations reported in one population, however, are rarely replicated in other 
      populations. We attempted to explore these associations by performing a 
      meta-analysis of published studies. Following a Medline search, we identified 
      four studies which presented raw data on all allele associations with CML 
      (significant and non-significant). Meta-analysis of these revealed a significant 
      risk association with the HLA-A*02 (pooled odds ratio 1.33, 95% confidence 
      interval 1.10-1.61) allele and a significant protective effect with the HLA-B*35 
      allele (pooled odds ratio 0.64, 95% confidence interval 0.48-0.86). To our 
      knowledge this is the first study to demonstrate the epidemiologic association 
      between HLA-A*02 and the risk of CML, and we discuss this in the context of 
      recent immunological studies reporting data on BCR-ABL fusion peptide 
      presentation and subsequent immune response. Our findings suggest that individual 
      epidemiological studies may lack statistical power, or may have other interfering 
      factors which prevent the unmasking of overall associations. Meta-analyses of 
      published studies may overcome these limitations and may prove useful in 
      uncovering allele-disease associations.
FAU - Naugler, Christopher
AU  - Naugler C
AD  - Department of Laboratory Medicine, Dalhousie University, Halifax, Nova Scotia, 
      Canada. christopher.naugler@cls.ca
FAU - Liwski, Robert
AU  - Liwski R
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Biomarkers, Tumor/*genetics
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*epidemiology/*genetics
MH  - Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2010/04/15 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.3109/10428191003802340 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2010 Jul;51(7):1288-92. doi: 10.3109/10428191003802340.