PMID- 20389501
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20211020
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Mar 1
TI  - Detection of lipid in atherosclerotic vessels using ultrasound-guided 
      spectroscopic intravascular photoacoustic imaging.
PG  - 4889-97
LID - 10.1364/OE.18.004889 [doi]
AB  - Lipid is a common constituent in atherosclerotic plaques. The location and area 
      of the lipid region is closely related to the progression of the disease. 
      Intravascular photoacoustic (IVPA) imaging, a minimally invasive imaging 
      modality, can spatially resolve the optical absorption property of arterial 
      tissue. Based on the distinct optical absorption spectrum of fat in the near 
      infrared wavelength range, spectroscopic IVPA imaging may distinguish lipid from 
      other water-based tissue types in the atherosclerotic artery. In this study, a 
      bench-top spectroscopic IVPA imaging system was used to ex-vivo image both 
      atherosclerotic and normal rabbit aortas. By combing the spectroscopic IVPA image 
      with the intravascular ultrasound (IVUS) image, lipid regions in the aorta were 
      identified. The results demonstrated that IVUS-guided spectroscopic IVPA imaging 
      is a promising tool to differentiate lipid in atherosclerosis.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Biomedical Engineering, University of Texas at Austin, TX 78712, 
      USA.
FAU - Su, Jimmy L
AU  - Su JL
FAU - Amirian, James
AU  - Amirian J
FAU - Litovsky, Silvio H
AU  - Litovsky SH
FAU - Smalling, Richard
AU  - Smalling R
FAU - Emelianov, Stanislav
AU  - Emelianov S
LA  - eng
GR  - R01 HL096981/HL/NHLBI NIH HHS/United States
GR  - HL096981/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - Absorption
MH  - *Acoustics
MH  - Animals
MH  - Atherosclerosis/*diagnostic imaging/*metabolism
MH  - Image Processing, Computer-Assisted
MH  - *Light
MH  - *Lipid Metabolism
MH  - Rabbits
MH  - Spectrum Analysis/*methods
MH  - Ultrasonography, Interventional/*methods
PMC - PMC3378348
EDAT- 2010/04/15 06:00
MHDA- 2010/07/09 06:00
PMCR- 2011/02/24
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
PHST- 2011/02/24 00:00 [pmc-release]
AID - 196110 [pii]
AID - 121713 [pii]
AID - 10.1364/OE.18.004889 [doi]
PST - ppublish
SO  - Opt Express. 2010 Mar 1;18(5):4889-97. doi: 10.1364/OE.18.004889.