PMID- 20390844
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20160526
IS  - 1532-4117 (Electronic)
IS  - 1093-4529 (Linking)
VI  - 45
IP  - 1
DP  - 2010
TI  - Heat-shock protein (Hsp70) and cytochrome P-450 (CYP1A) in the white mullet Mugil 
      curema (Pisces:Mugilidae) as biomarkers to assess environmental quality in 
      coastal lagoons.
PG  - 68-74
LID - 10.1080/10934520903388855 [doi]
AB  - Biomarkers have been useful tools to monitor some effects of pollution in coastal 
      environments. Hepatic expression of heat-shock protein 70 (Hsp70) and cytochrome 
      P450 1A (CYP1A) were analyzed in white mullet (Mugil curema) by RT-PCR from July, 
      2005 until July, 2006 in three coastal lagoons located in the southern Gulf of 
      California, Mexico. These three coastal systems receive contaminants derived from 
      local anthropogenic activities. Heat-shock proteins function to maintain protein 
      integrity in the presence of stressors (such as heat or chemicals) and can be 
      used as biomarkers of homeostatic alterations in polluted environments, whereas 
      cytochrome P450 family members participate in steroid hormone synthesis and 
      metabolism, and in xenobiotic transformation as a detoxification mechanism. The 
      expression levels of both genes showed consistency in time and space, and 
      presented a high overall correlation (r = 0.731, P < 0.001). Regardless of a high 
      individual variability, both genes presented higher expression levels in the 
      Urias Estuary (P < 0.001 and P < 0.05 for CYP1A and Hsp70, respectively), which 
      was considered the most polluted among the three systems, especially during the 
      rainy season (summer to fall). Gene expression levels were significantly 
      associated with non-halogenated hydrocarbon concentrations in sediments during 
      the sampling period (r = 0.686, P = 0.019 for CYP1A and r = 0.91, P < 0.001 for 
      Hsp70), suggesting that both genes respond to chemicals in the environment. The 
      results indicate that Mugil curema is a good candidate species to implement 
      biomonitoring programs in tropical coastal environments.
FAU - Rios-Sicairos, Julian
AU  - Rios-Sicairos J
AD  - Centro de Investigacion en Alimentacion y Desarrollo, Unidad Mazatlan, Mazatlan, 
      Mexico.
FAU - Betancourt-Lozano, Miguel
AU  - Betancourt-Lozano M
FAU - Leal-Tarin, Beatriz
AU  - Leal-Tarin B
FAU - Hernandez-Cornejo, Rubi
AU  - Hernandez-Cornejo R
FAU - Aguilar-Zarate, Gabriela
AU  - Aguilar-Zarate G
FAU - Garcia-De-La-Parra, Luz Maria
AU  - Garcia-De-La-Parra LM
FAU - Gutierrez, Jesus N
AU  - Gutierrez JN
FAU - Marquez-Rocha, Facundo
AU  - Marquez-Rocha F
FAU - Garcia-Gasca, Alejandra
AU  - Garcia-Gasca A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Environ Sci Health A Tox Hazard Subst Environ Eng
JT  - Journal of environmental science and health. Part A, Toxic/hazardous substances & 
      environmental engineering
JID - 9812551
RN  - 0 (Biomarkers)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Hydrocarbons)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cytochrome P-450 CYP1A1/genetics/*metabolism
MH  - *Environmental Monitoring
MH  - Female
MH  - Gene Expression
MH  - HSP70 Heat-Shock Proteins/genetics/*metabolism
MH  - Hydrocarbons/analysis
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Ovary/drug effects/growth & development/pathology
MH  - Seawater/analysis
MH  - Smegmamorpha/*physiology
MH  - Testis/drug effects/growth & development/pathology
MH  - Water Pollutants, Chemical/analysis/*toxicity
EDAT- 2010/04/15 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 917851830 [pii]
AID - 10.1080/10934520903388855 [doi]
PST - ppublish
SO  - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2010;45(1):68-74. doi: 
      10.1080/10934520903388855.