PMID- 20391044
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20131121
IS  - 1540-8566 (Electronic)
IS  - 0163-9366 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan
TI  - Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors 
      in institutionalized older adults: could a cyanocobalamin nasal spray be 
      beneficial?
PG  - 87-99
LID - 10.1080/01639360903574734 [doi]
AB  - The purpose of this study was to determine whether institutionalized older 
      individuals taking proton pump inhibitors (PPI) for more than 12 months were more 
      likely to have vitamin B(12) deficiency than individuals not taking PPI, and 
      whether cyanocobalamin nasal spray would improve their vitamin B(12) status. 
      Participants were long-term care residents aged 60-89 years. PPI users (n = 17) 
      were treated with cyanocobalamin nasal spray for 8 weeks; non-PPI users (n = 19) 
      were not treated but were followed for the same time duration. Serum samples from 
      all subjects were analyzed for vitamin B(12) and serum methylmalonic acid (sMMA) 
      at baseline and the end of the 8-week treatment. There was a significant 
      difference in mean vitamin B(12), sMMA, and frequency of deficiency between 
      control and intervention groups at baseline. After treatment, there was an 
      increase (p = 0.012) in serum vitamin B(12) concentration, and a decrease (p = 
      0.004) in frequency of deficiency in PPI users. Thus, we found that 
      institutionalized older individuals on PPI for more than 12 months may be more 
      likely to be vitamin B(12) deficient than non-PPI users. Additionally, treatment 
      of PPI users with cyanocobalamin nasal spray for 8 weeks could improve vitamin 
      B(12) status.
FAU - Rozgony, Nancy R
AU  - Rozgony NR
AD  - Department of Health, Nutrition, and Exercise Science, University of Delaware, 
      Newark, Delaware 19716, USA. nancy.rozgony@gmail.com
FAU - Fang, Chengshun
AU  - Fang C
FAU - Kuczmarski, Marie F
AU  - Kuczmarski MF
FAU - Bob, Harold
AU  - Bob H
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr Elder
JT  - Journal of nutrition for the elderly
JID - 8208739
RN  - 0 (Proton Pump Inhibitors)
RN  - 8LL8S712J7 (Methylmalonic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Administration, Inhalation
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Institutionalization
MH  - Long-Term Care
MH  - Male
MH  - Methylmalonic Acid/*blood
MH  - Middle Aged
MH  - Nutritional Status
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Vitamin B 12/blood/*therapeutic use
MH  - Vitamin B 12 Deficiency/*drug therapy/*etiology
EDAT- 2010/04/15 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 919592494 [pii]
AID - 10.1080/01639360903574734 [doi]
PST - ppublish
SO  - J Nutr Elder. 2010 Jan;29(1):87-99. doi: 10.1080/01639360903574734.