PMID- 20391302
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20100414
IS  - 1098-9064 (Electronic)
IS  - 0094-6176 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Feb
TI  - Toward effective long-term prevention of thromboembolism: novel oral 
      anticoagulant delivery systems.
PG  - 113-22
LID - 10.1055/s-0030-1248730 [doi]
AB  - Despite intensive research in the field of oral anticoagulants over the last 
      decade, simple and effective long-term prevention of thromboembolism is still an 
      unmet need. In addition to drug discovery approaches, the development of novel 
      oral drug delivery systems (DDSs) of clinically well-established anticoagulants 
      presents an intriguing mean of improvement of anticoagulant therapy. The latter 
      topic is therefore the focus of the present review. All relevant clinical trials 
      with anticoagulants formulated in the oral DDS are reviewed, and selected 
      preclinical examples of promising novel anticoagulant DDSs are also described. 
      For greater understanding, a background on DDS and drug absorption from the 
      gastrointestinal tract is also provided. Three leading approaches for the oral 
      anticoagulant DDS are currently being investigated in clinical settings, all 
      relying on coadministration of anticoagulants with specific carriers. In contrast 
      to the clinical setting, a diverse range of possibilities for oral delivery of 
      anticoagulant are being investigated in preclinical trials (e.g., 
      nanotechnology), and it would be therefore interesting to examine their 
      performance in clinical trials.
FAU - Homar, Miha
AU  - Homar M
AD  - SDC Slovenia, Lek Pharmaceuticals d.d., Ljubljana, Slovenia.
FAU - Cegnar, Mateja
AU  - Cegnar M
FAU - Kotnik, Miha
AU  - Kotnik M
FAU - Peternel, Luka
AU  - Peternel L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100413
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 0 (Anticoagulants)
RN  - 0 (Caprylates)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (N-(8-(2-hydroxybenzoyl)amino)caprylate)
SB  - IM
MH  - Administration, Oral
MH  - Anticoagulants/*administration & dosage/therapeutic use
MH  - Caprylates/administration & dosage
MH  - Clinical Trials as Topic
MH  - Drug Delivery Systems
MH  - Heparin, Low-Molecular-Weight/administration & dosage
MH  - Humans
MH  - Thromboembolism/*prevention & control
RF  - 91
EDAT- 2010/04/15 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1055/s-0030-1248730 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2010 Feb;36(1):113-22. doi: 10.1055/s-0030-1248730. Epub 
      2010 Apr 13.