PMID- 20394735
OWN - NLM
STAT- MEDLINE
DCOM- 20100707
LR  - 20131121
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 396
IP  - 2
DP  - 2010 May 28
TI  - Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis.
PG  - 182-6
LID - 10.1016/j.bbrc.2010.04.061 [doi]
AB  - Atherosclerosis is a chronic, complex, and progressive pathological process in 
      large and medium sized arteries. The exact mechanism of this process remains 
      unclear. Hydrogen sulfide (H(2)S), a novel gasotransmitter, was confirmed as 
      playing a major role in the pathogenesis of many cardiovascular diseases. It 
      plays a role in vascular smooth muscle cell (VSMC) proliferation and apoptosis, 
      participates in the progress of hyperhomocysteinemia (HHCY), inhibits atherogenic 
      modification of LDL, interferes with vascular calcification, intervenes with 
      platelet function, and there are interactions between H(2)S and inflammatory 
      processes. The role of H(2)S in atherosclerotic pathogenesis highlights the 
      mysteries of atherosclerosis and inspires the search for innovative therapeutic 
      strategies. Here, we review the studies to date that have considered the role of 
      H(2)S in atherosclerosis.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Qiao, Wang
AU  - Qiao W
AD  - Department of Pediatrics, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Chaoshu, Tang
AU  - Chaoshu T
FAU - Hongfang, Jin
AU  - Hongfang J
FAU - Junbao, Du
AU  - Junbao D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100413
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Lipoproteins, LDL)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Atherosclerosis/*etiology/metabolism/pathology
MH  - Blood Platelets/physiology
MH  - Calcinosis/metabolism
MH  - Cell Proliferation/drug effects
MH  - Humans
MH  - Hydrogen Sulfide/*metabolism/pharmacology
MH  - Hyperhomocysteinemia/metabolism
MH  - Inflammation/etiology/metabolism/pathology
MH  - Lipoproteins, LDL/metabolism
MH  - Muscle, Smooth, Vascular/drug effects/metabolism/*pathology
RF  - 50
EDAT- 2010/04/17 06:00
MHDA- 2010/07/08 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/02 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/08 06:00 [medline]
AID - S0006-291X(10)00730-8 [pii]
AID - 10.1016/j.bbrc.2010.04.061 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2010 May 28;396(2):182-6. doi: 
      10.1016/j.bbrc.2010.04.061. Epub 2010 Apr 13.