PMID- 2039813
OWN - NLM
STAT- MEDLINE
DCOM- 19910710
LR  - 20191022
IS  - 0142-2782 (Print)
IS  - 0142-2782 (Linking)
VI  - 12
IP  - 1
DP  - 1991 Jan-Feb
TI  - Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic 
      systems.
PG  - 73-9
AB  - Equations for the mean number of cycles through the peripheral system (R) and the 
      mean transit time through the central compartment (MTTc) are derived for 
      intravenous drugs with linear distribution and linear or nonlinear central 
      elimination. This R is a function of distribution clearance (CLD), dose, and area 
      under the plasma concentration-time curve (AUC). The MTTc is a function of the 
      central volume of distribution, CLD, dose, and AUC. The application of the 
      proposed calculations of R and MTTc was illustrated by computer simulations.
FAU - Cheng, H Y
AU  - Cheng HY
AD  - Department of Pharmaceutics, School of Pharmacy, State University of New York, 
      Buffalo 14260.
FAU - Jusko, W J
AU  - Jusko WJ
LA  - eng
GR  - 41037/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Biopharm Drug Dispos
JT  - Biopharmaceutics & drug disposition
JID - 7911226
SB  - IM
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intravenous
MH  - Mathematical Computing
MH  - Methods
MH  - Models, Biological
MH  - *Pharmacokinetics
MH  - Tissue Distribution
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1002/bdd.2510120108 [doi]
PST - ppublish
SO  - Biopharm Drug Dispos. 1991 Jan-Feb;12(1):73-9. doi: 10.1002/bdd.2510120108.