PMID- 20399085
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20220310
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 20
IP  - 9
DP  - 2010 Nov
TI  - High prevalence of vitamin D deficiency and its association with left ventricular 
      dilation: an echocardiography study in elderly patients with chronic heart 
      failure.
PG  - 633-40
LID - 10.1016/j.numecd.2010.01.002 [doi]
AB  - BACKGROUND AND AIMS: Vitamin D deficiency has been associated with chronic heart 
      failure (CHF). We evaluated vitamin D levels in relationship with New York Heart 
      Association (NYHA) classes, N-terminal pro-brain natriuretic peptide (NT-proBNP) 
      values and left ventricular (LV) measures in >/=60 year old patients with stable 
      CHF. Differently from previous investigations, LV function was assessed by 
      transthoracic echocardiography, to provide easily reproducible results. METHODS 
      AND RESULTS: The study was performed at geographic latitude 44 degrees  N, from March to 
      May and from September to November 2008. Acute HF and diseases or drugs altering 
      vitamin D status were exclusion criteria. NYHA scores and 25-hydroxyvitamin D 
      [25(OH)D], 1,25-dihydroxyvitamin D and NT-proBNP concentrations were assessed in 
      90 (45 F, 45 M) Caucasian patients with CHF secondary to hypertension and/or 
      coronary artery disease. Vitamin D levels were also measured in 31 subjects 
      without heart disease (controls). LV echocardiography was performed in 52 (26 F, 
      26 M) representative patients. Vitamin D concentrations were significantly lower 
      in CHF cases than in controls. Among subject with CHF, 97.8% presented vitamin D 
      deficiency (25(OH)D<75 nmol/L), being severe (<25 nmol/L) in 66.7%. LV 
      end-diastolic and end-systolic diameters were significantly longer, LV 
      end-diastolic and end-systolic volumes bigger and fractional shortening lower in 
      CHF patients with 25(OH)D<25 nmol/L than with 25(OH)D>/=25 nmol/L (p<0.05). 
      Log-values of 25(OH)D were negatively correlated with LV end-systolic diameter 
      and volume (r=-0.28; p<0.05). On subgroup analysis, these results persisted only 
      in male patients. CONCLUSIONS: In elderly CHF patients, vitamin D deficiency was 
      highly prevalent and often severe. This first addressed echocardiography study 
      showed a sex-specific association between vitamin D deficiency and LV dilation. 
      Since further echocardiography data are easily obtainable, larger investigations 
      are demanded.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Ameri, P
AU  - Ameri P
AD  - Department of Endocrinological and Medical Sciences, University of Genova, 
      Genova, Italy. pietroameri@unige.it
FAU - Ronco, D
AU  - Ronco D
FAU - Casu, M
AU  - Casu M
FAU - Denegri, A
AU  - Denegri A
FAU - Bovio, M
AU  - Bovio M
FAU - Menoni, S
AU  - Menoni S
FAU - Ferone, D
AU  - Ferone D
FAU - Murialdo, G
AU  - Murialdo G
LA  - eng
PT  - Journal Article
DEP - 20100415
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 1406-16-2 (Vitamin D)
RN  - 66772-14-3 (1,25-dihydroxyvitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
CIN - Nutr Metab Cardiovasc Dis. 2010 Nov;20(9):627-32. PMID: 20947319
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*complications/*diagnostic imaging/physiopathology
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/*complications/*epidemiology
EDAT- 2010/04/20 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2009/10/31 00:00 [revised]
PHST- 2010/01/01 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S0939-4753(10)00010-4 [pii]
AID - 10.1016/j.numecd.2010.01.002 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2010 Nov;20(9):633-40. doi: 
      10.1016/j.numecd.2010.01.002. Epub 2010 Apr 15.