PMID- 20399121
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20211020
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 32
IP  - 4
DP  - 2010 Apr 23
TI  - E-cadherin marks a subset of inflammatory dendritic cells that promote T 
      cell-mediated colitis.
PG  - 557-67
LID - 10.1016/j.immuni.2010.03.017 [doi]
AB  - Dendritic cells (DCs) play a pivotal role in controlling the balance between 
      tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote 
      regulatory T (Treg) cell responses; however, little is known about DCs that drive 
      inflammation in the intestine. Here, we show that monocyte-derived inflammatory 
      DCs that express E-cadherin, the receptor for CD103, promote intestinal 
      inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph 
      nodes and colon, had high expression of toll-like receptors, and produced 
      colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, 
      adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts 
      increased Th17 cell responses in the intestine and led to exacerbation of 
      colitis. These results identify a monocyte-derived inflammatory DC subset that is 
      associated with the pathogenesis of intestinal inflammation, providing a 
      therapeutic target for the treatment of inflammatory bowel disease.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Siddiqui, Karima R R
AU  - Siddiqui KR
AD  - Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
FAU - Laffont, Sophie
AU  - Laffont S
FAU - Powrie, Fiona
AU  - Powrie F
LA  - eng
GR  - Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100415
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, CD)
RN  - 0 (CD11c Antigen)
RN  - 0 (Cadherins)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (alpha E integrins)
SB  - IM
CIN - Immunity. 2010 Apr 23;32(4):502-4. PMID: 20412761
MH  - Animals
MH  - Antigens, CD/immunology
MH  - CD11c Antigen/immunology
MH  - Cadherins/*immunology
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Colitis/genetics/*immunology/pathology
MH  - Dendritic Cells/cytology/*immunology
MH  - Gene Expression Regulation
MH  - Immunity, Innate
MH  - Inflammation/immunology
MH  - Integrin alpha Chains/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Monocytes/cytology/immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC2938478
EDAT- 2010/04/20 06:00
MHDA- 2010/05/07 06:00
PMCR- 2010/04/23
CRDT- 2010/04/20 06:00
PHST- 2009/07/19 00:00 [received]
PHST- 2009/12/14 00:00 [revised]
PHST- 2010/02/11 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
PHST- 2010/04/23 00:00 [pmc-release]
AID - S1074-7613(10)00124-X [pii]
AID - 10.1016/j.immuni.2010.03.017 [doi]
PST - ppublish
SO  - Immunity. 2010 Apr 23;32(4):557-67. doi: 10.1016/j.immuni.2010.03.017. Epub 2010 
      Apr 15.