PMID- 20399205
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20211020
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Print)
IS  - 0014-4800 (Linking)
VI  - 89
IP  - 1
DP  - 2010 Aug
TI  - MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal 
      epithelia in multiple exocrine organs of transgenic mice.
PG  - 9-19
LID - 10.1016/j.yexmp.2010.03.009 [doi]
AB  - Caveolin-1 (Cav-1) is a major structural protein of caveolae, specialized plasma 
      membrane invaginations that are involved in a cell-specific fashion in diverse 
      cell activities such as molecular transport, cell adhesion, and signal 
      transduction. In normal adult mammals, Cav-1 expression is abundant in 
      mesenchyme-derived cells but relatively low in epithelial parenchyma. However, 
      epithelial Cav-1 overexpression is associated with development and/or progression 
      of many carcinomas. In this study, we generated and characterized a transgenic 
      mouse model of Cav-1 overexpression under the control of a mouse mammary tumor 
      virus (MMTV) long terminal-repeat promoter, which is predominantly expressed in 
      specific epithelial cells. The MMTVcav-1(+) transgenic mice were fertile, and 
      females bore litters of normal size with no obvious developmental abnormalities. 
      However, by age 11months, the MMTVcav-1(+) mice demonstrated overtly different 
      phenotypes in multiple exocrine organs when compared with their nontransgenic 
      MMTVcav-1(-) littermates. Cav-1 overexpression in MMTVcav-1(+) mice produced 
      organ-specific abnormalities, including hypotrophy of mammary glandular 
      epithelia, bronchiolar epithelial hyperplasia and atypia, mucous-cell hyperplasia 
      in salivary glands, elongated hair follicles and dermal thickening in the skin, 
      and reduced accumulation of enzymogen granules in pancreatic acinar cells. In 
      addition, the MMTVcav-1(+) transgenic mice tended to have a greater incidence of 
      malignant tumors, including lung and liver carcinomas and lymphoma, than their 
      MMTVcav-1(-) littermates. Our results indicate that Cav-1 overexpression causes 
      organ-specific, age-related epithelial disorders and suggest the potential for 
      increased susceptibility to carcinogenesis.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Yang, Guang
AU  - Yang G
AD  - Department of Genitourinary Medical Oncology-Research, Unit 18-3, The University 
      of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 
      77030-4009, USA. guangyang@mdanderson.org
FAU - Park, Sanghee
AU  - Park S
FAU - Cao, Guangwen
AU  - Cao G
FAU - Goltsov, Alexei
AU  - Goltsov A
FAU - Ren, Chengzhen
AU  - Ren C
FAU - Truong, Luan D
AU  - Truong LD
FAU - Demayo, Francesco
AU  - Demayo F
FAU - Thompson, Timothy C
AU  - Thompson TC
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - CA 16672/CA/NCI NIH HHS/United States
GR  - CA R0168814/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100422
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Caveolin 1)
SB  - IM
MH  - Abnormalities, Multiple/*genetics
MH  - Animals
MH  - Caveolin 1/*genetics
MH  - Cells, Cultured
MH  - Epithelium/metabolism/*pathology
MH  - Exocrine Glands/*abnormalities
MH  - Female
MH  - Gene Expression Regulation/*physiology
MH  - Hyperplasia
MH  - Incidence
MH  - Liver Neoplasms/genetics
MH  - Lung Neoplasms/genetics
MH  - Male
MH  - Mammary Glands, Animal/abnormalities
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Promoter Regions, Genetic/*genetics
MH  - Skin/metabolism/pathology
PMC - PMC3881545
MID - NIHMS198149
COIS- Conflict of interest statement The authors declare that there are no conflicts of 
      interest.
EDAT- 2010/04/20 06:00
MHDA- 2010/08/04 06:00
PMCR- 2014/01/06
CRDT- 2010/04/20 06:00
PHST- 2010/03/12 00:00 [received]
PHST- 2010/03/31 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
PHST- 2014/01/06 00:00 [pmc-release]
AID - S0014-4800(10)00052-3 [pii]
AID - 10.1016/j.yexmp.2010.03.009 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2010 Aug;89(1):9-19. doi: 10.1016/j.yexmp.2010.03.009. Epub 2010 
      Apr 22.