PMID- 20399811
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20211203
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1803
IP  - 9
DP  - 2010 Sep
TI  - The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of 
      rapamycin signaling network in normal myelopoiesis and leukemogenesis.
PG  - 991-1002
LID - 10.1016/j.bbamcr.2010.04.005 [doi]
AB  - The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) 
      signaling pathway mediates diverse and important physiological cell functions 
      which include proliferation, differentiation, survival, motility, autophagy, and 
      metabolism. However, dysregulated PI3K/Akt/mTOR signaling has been documented in 
      a wide range of neoplasias, including malignant hematological disorders. It is 
      now emerging that this signaling network plays a key role during normal 
      hematopoiesis, a tightly regulated process resulting in the formation of all 
      blood lineages. Blood cell development encompasses a complex series of events 
      which are mainly regulated by actions of cytokines, a family of extracellular 
      ligands which stimulate many biological responses in a wide array of cell types. 
      Hematopoiesis is strictly dependent on the correct function of the bone marrow 
      microenvironment (BMM), as BMM cells secrete most of the cytokines. Several of 
      these cytokines activate the PI3K/Akt/mTOR signaling network and regulate 
      proliferation, survival, and differentiation events during hematopoiesis. Here, 
      we review the evidence that links the signals emanating from the PI3K/Akt/mTOR 
      cascade with the functions of hematopoietic stem cells and the process of 
      myelopoiesis, including lineage commitment. We then highlight the emerging role 
      played by aberrant PI3K/Akt/mTOR signaling during leukemogenesis.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Martelli, Alberto M
AU  - Martelli AM
AD  - Department of Human Anatomy, University of Bologna, via Irnerio 48, 40126 
      Bologna, Italy. alberto.martelli@unibo.it
FAU - Evangelisti, Camilla
AU  - Evangelisti C
FAU - Chiarini, Francesca
AU  - Chiarini F
FAU - Grimaldi, Cecilia
AU  - Grimaldi C
FAU - Cappellini, Alessandra
AU  - Cappellini A
FAU - Ognibene, Andrea
AU  - Ognibene A
FAU - McCubrey, James A
AU  - McCubrey JA
LA  - eng
GR  - R01098195/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100423
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/physiology
MH  - Leukemia/*genetics/pathology
MH  - Mammals/genetics/metabolism
MH  - Models, Biological
MH  - Myelopoiesis/*genetics/physiology
MH  - Phosphatidylinositol 3-Kinases/genetics/metabolism/physiology
MH  - Protein Serine-Threonine Kinases/genetics/physiology
MH  - Proto-Oncogene Proteins c-akt/genetics/metabolism/physiology
MH  - Signal Transduction/genetics/physiology
MH  - TOR Serine-Threonine Kinases
RF  - 0
EDAT- 2010/04/20 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/04/06 00:00 [revised]
PHST- 2010/04/06 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - S0167-4889(10)00111-4 [pii]
AID - 10.1016/j.bbamcr.2010.04.005 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2010 Sep;1803(9):991-1002. doi: 
      10.1016/j.bbamcr.2010.04.005. Epub 2010 Apr 23.