PMID- 20399882
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20201219
IS  - 1879-1107 (Electronic)
IS  - 1096-4959 (Linking)
VI  - 157
IP  - 1
DP  - 2010 Sep
TI  - 1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes 
      than 1-D-methyltryptophan.
PG  - 10-5
LID - 10.1016/j.cbpb.2010.04.006 [doi]
AB  - 1-D-methyltryptophan (D-1MT) is an effective anti-cancer agent in mouse tumour 
      models. It has been suggested to be a selective inhibitor of the recently 
      described tryptophan-degrading enzyme indoleamine 2,3-dioxygenase 2 (IDO2) rather 
      than the closely related enzyme IDO1. We found that mammalian (mouse, opossum and 
      platypus), chicken, frog, and fish IDO2 could be functional 
      tryptophan-catabolising enzymes. The characteristics of pH-dependent activity and 
      inhibitor selectivity were conserved amongst the vertebrate IDO2 proteins tested. 
      Like IDO1 enzymes, the enzymatic activity of all IDO2s was inhibited by L-1MT but 
      not by D-1MT in a cell-free assay. When IDO2s were expressed in mammalian cells, 
      L-1MT was also a better inhibitor than D-1MT.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Yuasa, Hajime J
AU  - Yuasa HJ
AD  - Laboratory of Biochemistry, Department of Applied Science, Faculty of Science, 
      National University Corporation Kochi University, Kochi 780-8520, Japan. 
      julie@kochi-u.ac.jp
FAU - Ball, Helen J
AU  - Ball HJ
FAU - Austin, Christopher J D
AU  - Austin CJ
FAU - Hunt, Nicholas H
AU  - Hunt NH
LA  - eng
PT  - Journal Article
DEP - 20100423
PL  - England
TA  - Comp Biochem Physiol B Biochem Mol Biol
JT  - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
JID - 9516061
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 7303-49-3 (tryptophan methyl ester)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Animals
MH  - Anura
MH  - Chickens
MH  - Cloning, Molecular
MH  - Enzyme Inhibitors/*chemistry/*pharmacology
MH  - Fishes
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & 
      inhibitors/genetics/metabolism
MH  - Kinetics
MH  - Mice
MH  - Stereoisomerism
MH  - Substrate Specificity
MH  - Tryptophan/*analogs & derivatives/chemistry/pharmacology
EDAT- 2010/04/20 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/12/23 00:00 [received]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/04/13 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - S1096-4959(10)00100-4 [pii]
AID - 10.1016/j.cbpb.2010.04.006 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B Biochem Mol Biol. 2010 Sep;157(1):10-5. doi: 
      10.1016/j.cbpb.2010.04.006. Epub 2010 Apr 23.