PMID- 20401333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1177-9314 (Print)
IS  - 1177-9314 (Electronic)
IS  - 1177-9314 (Linking)
VI  - 2008
IP  - 2
DP  - 2008 Apr 1
TI  - Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma.
PG  - 169-179
AB  - Disruptions of beta-catenin and the canonical Wnt pathway are well documented in 
      cancer. However, little is known of the non-canonical branch of the Wnt pathway. 
      In this study, we investigate the transcript level patterns of genes in the Wnt 
      pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was 
      found that over half of the samples examined exhibited dysregulated gene 
      expression of multiple components of the non-canonical branch of the WNT pathway. 
      In the cases where beta catenin (CTNNB1) was not over-expressed, we identified 
      strong relationships of expression between wingless-type MMTV integration site 
      family member 5A (WNT5A)/ frizzled homolog 2 (FZD2), frizzled homolog 3 (FZD3) / 
      dishevelled 2 (DVL2), and low density lipoprotein receptor-related protein 5 
      (LRP5)/ secreted frizzled-related protein 4 (SFRP4). This is one of the first 
      studies to demonstrate expression of genes in the non-canonical pathway in normal 
      lung tissue and its disruption in lung squamous cell carcinoma. These findings 
      suggest that the non-canonical pathway may have a more prominent role in lung 
      cancer than previously reported.
FAU - Lee, Eric H L
AU  - Lee EH
AD  - Department of Cancer Genetics and Developmental Biology, BC Cancer Agency 
      Research Centre, Vancouver, BC, Canada.
FAU - Chari, Raj
AU  - Chari R
FAU - Lam, Andy
AU  - Lam A
FAU - Ng, Raymond T
AU  - Ng RT
FAU - Yee, John
AU  - Yee J
FAU - English, John
AU  - English J
FAU - Evans, Kenneth G
AU  - Evans KG
FAU - Macaulay, Calum
AU  - Macaulay C
FAU - Lam, Stephen
AU  - Lam S
FAU - Lam, Wan L
AU  - Lam WL
LA  - eng
GR  - R01 DE015965/DE/NIDCR NIH HHS/United States
GR  - R01 DE015965-01/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PL  - New Zealand
TA  - Clin Med Oncol
JT  - Clinical medicine. Oncology
JID - 101467911
PMC - PMC2855195
MID - NIHMS142348
EDAT- 2008/04/01 00:00
MHDA- 2008/04/01 00:01
PMCR- 2008/04/01
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2008/04/01 00:00 [pubmed]
PHST- 2008/04/01 00:01 [medline]
PHST- 2008/04/01 00:00 [pmc-release]
AID - cmo-2-2008-169 [pii]
PST - ppublish
SO  - Clin Med Oncol. 2008 Apr 1;2008(2):169-179.