PMID- 20401448
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20161125
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 62
IP  - 2
DP  - 2010 Apr 25
TI  - [Comparison of hemogram changes under chronic intermittent hypoxia in 
      Lasiopodomys mandarinus and Kunming Mus musculus].
PG  - 137-42
AB  - Mandarin vole (Lasiopodomys mandarinus) spends almost all of its life underground 
      and must have evolved remarkable adaptations to cope with the subterranean 
      hypoxic stress. The aim of present study is to explore the adaptation mechanism 
      through the comparison of hemogram changes under chronic intermittent hypoxia in 
      Mandarin vole and Kunming (KM) mouse (Mus musculus). Mandarin vole and KM mouse 
      were treated with chronic intermittent hypoxia (10.0% oxygen), which was 
      maintained by an oxygen cabin, for 4 h per day during four weeks. Then blood 
      samples from the animals with and without hypoxia treatment were analyzed by a 
      hematology analyzer. The results showed that under normoxic condition mean 
      corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), white blood cell 
      count (WBC) and platelet (PLT) in Mandarin vole were significantly lower than 
      those in KM mouse. On the contrast, red blood cell count (RBC) and mean 
      corpuscular hemoglobin concentration (MCHC) in Mandarin vole were higher than 
      that in KM mouse. After four-week chronic intermittent hypoxia treatment, the 
      hemogram changes were as following. MCV and HCT were elevated in Mandarin vole, 
      not affected in KM mouse. Both hemoglobin (HGB) content and MCH in KM mouse 
      increased, while only MCH increased in Mandarin vole. No obvious changes of WBC 
      and PLT were found in two species. These results suggest that the adaptive 
      mechanism of blood system in Mandarin vole responding to hypoxic conditions is 
      different from that of KM mouse. As a subterranean vole, the Mandarin vole has a 
      better tolerance to hypoxia.
FAU - Liu, Bin
AU  - Liu B
AD  - Institute of Biodiversity and Ecology, Zhengzhou University, Zhengzhou 450001, 
      China.
FAU - Wang, Zhen-Long
AU  - Wang ZL
FAU - Lu, Ji-Qi
AU  - Lu JQ
FAU - Yang, Yan-Yan
AU  - Yang YY
LA  - chi
PT  - Comparative Study
PT  - Journal Article
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Animals
MH  - Arvicolinae/*blood
MH  - Chronic Disease
MH  - Erythrocytes
MH  - Hemoglobins
MH  - Hypoxia/*blood
MH  - Mice/*blood
MH  - Species Specificity
EDAT- 2010/04/20 06:00
MHDA- 2013/01/25 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2010 Apr 25;62(2):137-42.