PMID- 20401687
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20211020
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 30 Suppl 1
DP  - 2010 May
TI  - Adoptive-transfer effects of intravenous immunoglobulin in autoimmunity.
PG  - S20-3
LID - 10.1007/s10875-010-9410-9 [doi]
AB  - Intravenous immunoglobulin (IVIG) is an effective treatment for a variety of 
      autoimmune and inflammatory conditions. The mechanism of action of IVIG remains 
      poorly understood, but a variety of theories have been suggested. Recent studies 
      in murine models have indicated that some of the ameliorative effects of IVIG in 
      autoimmunity can be repeated by the adoptive transfer of leukocytes that have 
      been primed with IVIG. The active cell component within the leukocyte cell 
      population in immune thrombocytopenia (ITP) was determined to be CD11c(+) 
      dendritic cells. This review will highlight recent work in murine systems that 
      indicates that the effects of IVIG can be adoptively transferred in some 
      autoimmune diseases and inflammatory states.
FAU - Lazarus, Alan H
AU  - Lazarus AH
AD  - The Canadian Blood Services, Ottawa, ON, Canada. lazarusa@smh.toronto.on.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Abortion, Habitual/immunology/therapy
MH  - *Adoptive Transfer
MH  - Animals
MH  - Antigen-Antibody Complex/immunology
MH  - Arthritis, Experimental/immunology/therapy
MH  - Autoimmune Diseases/immunology/*therapy
MH  - Dendritic Cells/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Resorption/immunology
MH  - Immunoglobulins, Intravenous/immunology/pharmacology/*therapeutic use
MH  - Inflammation/immunology/therapy
MH  - Leukocytes/drug effects/immunology
MH  - Mice
MH  - Models, Immunological
MH  - Pregnancy
MH  - Purpura, Thrombocytopenic, Idiopathic/immunology/therapy
MH  - Receptors, IgG/immunology
EDAT- 2010/04/20 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1007/s10875-010-9410-9 [doi]
PST - ppublish
SO  - J Clin Immunol. 2010 May;30 Suppl 1:S20-3. doi: 10.1007/s10875-010-9410-9.