PMID- 20403136
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 1
DP  - 2010 Jul
TI  - Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA-DRB1 
      region in Iranian population.
PG  - 60-3
LID - 10.1111/j.1399-0039.2010.01467.x [doi]
AB  - Genomewide screen analysis has shown the close association of the human leukocyte 
      antigen (HLA)-DRB1 region with susceptibility to multiple sclerosis and a number 
      of autoimmune diseases. Using bioinformatics software, several potential short 
      tandem repeat (STR) markers have been introduced in this region in the major 
      histocompatibility complex data base (dbMHC). In this study, the identity and 
      characteristics of two putative STR markers, D6S2879 and D6S2806, in this region 
      were examined in Iranian population. The loci were genotyped in 85 individuals 
      using polymerase chain reaction followed by polyacrylamide gel electrophoresis 
      and sequencing. Analysis of the allelic frequency showed the presence of six and 
      four alleles for D6S2806 and D6S2879, respectively. Analysis of deviations from 
      Hardy-Weinberg equilibrium (HWE) showed that D6S2806 was in equilibrium (P > 
      0.05). However, the D6S2879 locus showed a significant deviation from HWE (P < 
      0.05). Therefore, the D6S2806 locus could be suggested as a marker for linkage 
      analysis and disease-susceptibility investigations in the MHC-DRB1 gene region.
FAU - Vallian, S
AU  - Vallian S
AD  - Division of Genetics, Department of Biology, Faculty of Science, University of 
      Isfahan, Isfahan, Islamic Republic of Iran. svallian@biol.ui.ac.ir
FAU - Tajadod, M
AU  - Tajadod M
FAU - Hojati, Z
AU  - Hojati Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100406
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Databases, Genetic
MH  - *Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Iran
MH  - Microsatellite Repeats/*genetics
MH  - Sequence Alignment
EDAT- 2010/04/21 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TAN1467 [pii]
AID - 10.1111/j.1399-0039.2010.01467.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Jul;76(1):60-3. doi: 10.1111/j.1399-0039.2010.01467.x. Epub 
      2010 Apr 6.