PMID- 20403731
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20131121
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 136
IP  - 2
DP  - 2010 Aug
TI  - Effect of combining ACE inhibitor and statin in lupus-prone mice.
PG  - 188-96
LID - 10.1016/j.clim.2010.03.008 [doi]
AB  - MRL-Fas(lpr) mice spontaneously develop a systemic autoimmune disease resembling 
      human systemic lupus erythematosus. The glomerulonephritis in MRL-Fas(lpr) mice 
      is mediated by autoantibodies and autoreactive lymphocytes. To investigate the 
      effect of combination therapy by angiotensin-converting enzyme inhibitor (ACEI) 
      and hydroxymethylglutaryl-coenzyme A reductase inhibitor (statin) for lupus 
      nephritis, we treated MRL-Fas(lpr) mice with imidapril, pravastatin or both 
      agents. Compared with other groups, the mice treated by combination therapy 
      survived longer and showed a significant reduction in proteinuria, renal 
      pathology, including glomerular IgG deposit, and serum anti-DNA Ab. Furthermore, 
      monocyte chemoattractant protein-1 (MCP-1) in the kidney was reduced 
      significantly in the combination therapy group, compared with that in the control 
      group. We conclude that combination therapy with ACEI and statin for MRL-Fas(lpr) 
      mice significantly alleviates autoimmune renal disorder and prolongs survival. 
      These results suggest that combination therapy by ACEI and statin may represent a 
      new approach to the treatment of patients with lupus.
FAU - Shimazu, Hideki
AU  - Shimazu H
AD  - Department of Nephrology and Rheumatology, Kinki University School of Medicine, 
      Osaka-Sayama, Osaka, Japan.
FAU - Kinoshita, Koji
AU  - Kinoshita K
FAU - Hino, Shoichi
AU  - Hino S
FAU - Yano, Tomohiro
AU  - Yano T
FAU - Kishimoto, Kazuya
AU  - Kishimoto K
FAU - Nagare, Yasuaki
AU  - Nagare Y
FAU - Nozaki, Yuji
AU  - Nozaki Y
FAU - Sugiyama, Masafumi
AU  - Sugiyama M
FAU - Ikoma, Shinya
AU  - Ikoma S
FAU - Funauchi, Masanori
AU  - Funauchi M
LA  - eng
PT  - Journal Article
DEP - 20100418
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Cytokines)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Imidazolidines)
RN  - 0 (Immunoglobulin G)
RN  - BW7H1TJS22 (imidapril)
RN  - KXO2KT9N0G (Pravastatin)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*administration & dosage
MH  - Animals
MH  - Antibodies, Antinuclear/blood
MH  - Blood Pressure
MH  - Cytokines/metabolism
MH  - Drug Therapy, Combination
MH  - Female
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
MH  - Imidazolidines/*administration & dosage
MH  - Immunoglobulin G/metabolism
MH  - Kidney/immunology/metabolism/pathology
MH  - Lupus Erythematosus, Systemic/*drug therapy/immunology
MH  - Lupus Nephritis/drug therapy/immunology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred MRL lpr
MH  - Pravastatin/*administration & dosage
MH  - Proteinuria/drug therapy/prevention & control
MH  - Random Allocation
MH  - Specific Pathogen-Free Organisms
EDAT- 2010/04/21 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/04/21 06:00
PHST- 2009/08/13 00:00 [received]
PHST- 2010/03/18 00:00 [revised]
PHST- 2010/03/18 00:00 [accepted]
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - S1521-6616(10)00090-2 [pii]
AID - 10.1016/j.clim.2010.03.008 [doi]
PST - ppublish
SO  - Clin Immunol. 2010 Aug;136(2):188-96. doi: 10.1016/j.clim.2010.03.008. Epub 2010 
      Apr 18.