PMID- 2040385
OWN - NLM
STAT- MEDLINE
DCOM- 19910710
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 40
IP  - 6
DP  - 1991 Jun
TI  - Effects of lipid on basal carbohydrate metabolism in normal men.
PG  - 686-92
AB  - We investigated the effects of infusion of a 20% triglyceride emulsion plus 
      heparin (LH) on carbohydrate (CHO) metabolism during basal insulin and glucose 
      turnover conditions in normal male subjects. In study 1, LH or saline was infused 
      at 0.5 and 1.5 ml/min for 2 h each. Plasma free fatty acids rose from 
      approximately 0.4 to 0.8 mM with the low rate and to between 1.6 and 2.1 mM with 
      the high rate. Similar increases occurred in plasma concentrations of glycerol, 
      acetoacetate, and beta-hydroxybutyrate. LH infusions resulted in significant 
      increases in C-peptide concentrations but had no effects on any of the other 
      measured parameters of CHO metabolism. In study 2, LH or saline was infused as in 
      study 1, but the compensatory insulin release was prevented by intravenous 
      infusion of somatostatin and replacement of basal insulin and glucagon 
      concentrations. This resulted in significant increases in plasma glucose (from 
      4.5 +/- 0.2 to 7.1 +/- 0.6 mM, P less than 0.001) and hepatic glucose output 
      (from 9.0 +/- 1.5 to 11.3 +/- 1.4 mumol.kg-1.min-1, P less than 0.05) and a 
      decrease in glucose clearance (from 2.32 +/- 0.13 to 1.44 +/- 0.11 ml.kg-1.min-1, 
      P less than 0.05). We conclude that lipids can have adverse effects on CHO 
      metabolism under basal conditions and that healthy individuals can compensate for 
      these effects with additional secretion of insulin.
FAU - Boden, G
AU  - Boden G
AD  - Department of Medicine, Temple University School of Medicine, Philadelphia, 
      Pennsylvania 19104.
FAU - Jadali, F
AU  - Jadali F
LA  - eng
GR  - AG-07988/AG/NIA NIH HHS/United States
GR  - RR-349/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Acetoacetates)
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Emulsions)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hydroxybutyrates)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 9005-49-6 (Heparin)
RN  - PDC6A3C0OX (Glycerol)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid
MH  - Acetoacetates/blood
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - C-Peptide/blood
MH  - *Carbohydrate Metabolism
MH  - Emulsions
MH  - Fatty Acids, Nonesterified/blood
MH  - Glycerol/blood
MH  - Heparin/administration & dosage/pharmacology
MH  - Humans
MH  - Hydroxybutyrates/blood
MH  - Infusions, Intravenous
MH  - Insulin/*blood/metabolism
MH  - Insulin Secretion
MH  - Kinetics
MH  - Male
MH  - Reference Values
MH  - Time Factors
MH  - Triglycerides/administration & dosage/*pharmacology
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 10.2337/diab.40.6.686 [doi]
PST - ppublish
SO  - Diabetes. 1991 Jun;40(6):686-92. doi: 10.2337/diab.40.6.686.