PMID- 20404354
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101115
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 25
IP  - 11
DP  - 2010 Nov
TI  - Familial recurrent hypersomnia: two siblings with Kleine-Levin syndrome and 
      menstrual-related hypersomnia.
PG  - 1408-10
LID - 10.1177/0883073810366599 [doi]
AB  - Kleine-Levin syndrome and menstrual-related hypersomnia are rare idiopathic sleep 
      disorders occurring primarily in adolescence. They are characterized by 
      intermittent periods of excessive sleepiness, cognitive disturbances, and 
      behavioral abnormalities. In both, the etiology remains unknown but autoinmune, 
      hormonal, infectious, and inflammatory mechanisms have been proposed. The authors 
      describe, for the first time, the association of Kleine-Levin syndrome and 
      menstrual-related hypersomnia in 2 adolescent siblings who shared the human 
      leukocyte antigen (HLA) loci DQB1*0501. The same haplotype has been associated 
      with sleepwalking and with rapid eye movement (REM) sleep behavior disorder. This 
      gender differences in the manifestation of a probably genetic influenced sleep 
      disorder suggests that hormonal mechanisms could be implicated in the 
      phenotypical expression of this sleep disorder. The male sibling with 
      Kleine-Levin syndrome was easily controlled with carbamazepine in low doses, but 
      his sister could be only efficaciously treated with oral contraceptives.
FAU - Rocamora, Rodrigo
AU  - Rocamora R
AD  - Department of Neurology, Hospital del Mar, Barcelona, Spain. 
      rrocamora@imas.imim.es
FAU - Gil-Nagel, Antonio
AU  - Gil-Nagel A
FAU - Franch, Oriol
AU  - Franch O
FAU - Vela-Bueno, Antonio
AU  - Vela-Bueno A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100419
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - Adolescent
MH  - Disorders of Excessive Somnolence/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Menstrual Cycle
MH  - Siblings
EDAT- 2010/04/21 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 0883073810366599 [pii]
AID - 10.1177/0883073810366599 [doi]
PST - ppublish
SO  - J Child Neurol. 2010 Nov;25(11):1408-10. doi: 10.1177/0883073810366599. Epub 2010 
      Apr 19.