PMID- 20404719 OWN - NLM STAT- MEDLINE DCOM- 20100810 LR - 20100504 IS - 1538-943X (Electronic) IS - 1058-2916 (Linking) VI - 56 IP - 3 DP - 2010 May-Jun TI - A novel bioimpedance technique to monitor fluid volume state during hemodialysis treatment. PG - 215-20 LID - 10.1097/MAT.0b013e3181d89160 [doi] AB - Bioimpedance spectroscopy is a potential candidate for monitoring of body fluids during dialysis. In this article, the suitability of knee-to-knee (KK) as an alternative to wrist-to-ankle (WA) bioimpedance spectroscopy measurements during dialysis is evaluated. Measurements on eight patients (22 dialysis sessions) showed a good correlation between the change in extracellular resistance (Re) in KK and WA measurements. A deeper analysis indicated that the change in Re normalized for ultrafiltrated volume [DeltaRe/UFV (%/L)] depends on the characteristics of the patient: clinically stable patients [with a presumed lower extracellular fluid - total body volume (VB) relationship] show a higher DeltaRe/UFV (%/L) mean +/- standard deviation (WA: 8.90 +/- 1.9 and KK: 8.29 +/- 2.2) than clinically unstable patients with pitting peripheral edema (WA: 2.10 +/- 0.8 and KK: 2.07 +/- 0.2). Simulations based on bioimpedance equations considering Hanai theory confirm the results. The KK method, especially in combination with proper use of the introduced DeltaRe/UFV (%/L) normalization could possibly offer new options for comfortable online monitoring and the evaluation of fluid volume state during dialysis. FAU - Medrano, Guillermo AU - Medrano G AD - Philips Chair for Medical Information Technology (MedIT), Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. medrano@hia.rwth-aachen.de FAU - Eitner, Frank AU - Eitner F FAU - Floege, Jurgen AU - Floege J FAU - Leonhardt, Steffen AU - Leonhardt S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - ASAIO J JT - ASAIO journal (American Society for Artificial Internal Organs : 1992) JID - 9204109 SB - IM MH - Adult MH - Aged MH - Ankle MH - Ankle Joint MH - Body Composition MH - Body Fluids MH - Drug Administration Routes MH - Extracellular Fluid MH - Extracellular Space MH - Female MH - Humans MH - Male MH - Middle Aged MH - Renal Dialysis/*methods MH - Spectrum Analysis/methods MH - Wrist MH - Wrist Joint EDAT- 2010/04/21 06:00 MHDA- 2010/08/11 06:00 CRDT- 2010/04/21 06:00 PHST- 2010/04/21 06:00 [entrez] PHST- 2010/04/21 06:00 [pubmed] PHST- 2010/08/11 06:00 [medline] AID - 10.1097/MAT.0b013e3181d89160 [doi] PST - ppublish SO - ASAIO J. 2010 May-Jun;56(3):215-20. doi: 10.1097/MAT.0b013e3181d89160.