PMID- 20405183
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20211020
IS  - 1573-2592 (Electronic)
IS  - 0271-9142 (Linking)
VI  - 30 Suppl 1
DP  - 2010 May
TI  - Immunomodulation by intravenous immunoglobulin: role of regulatory T cells.
PG  - S4-8
LID - 10.1007/s10875-010-9394-5 [doi]
AB  - An altered immune homeostasis as a result of deficiency or defective function of 
      CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) is common in several autoimmune 
      diseases. Hence, therapeutic strategies to render Tregs functionally competent 
      are being investigated. Intravenous immunoglobulin (IVIG) is being increasingly 
      used for the treatment of a wide range of autoimmune and inflammatory diseases. 
      Recent studies have demonstrated that IVIG induces the expansion of Tregs and 
      enhances their suppressive functions. These effects of IVIG on Tregs correlate 
      with the beneficial effects of IVIG in patients with autoimmune diseases. Thus, 
      modulation of Tregs by IVIG represents a novel mode of action that explains the 
      therapeutic effects of IVIG in T cell-mediated autoimmune diseases. However, the 
      molecular mechanisms involved in IVIG-mediated modulation of Tregs are unclear 
      and need further investigation.
FAU - Maddur, Mohan S
AU  - Maddur MS
AD  - Unite 872, Institut National de la Sante et de la Recherche Medicale Paris, 
      Paris, France.
FAU - Othy, Shivashankar
AU  - Othy S
FAU - Hegde, Pushpa
AU  - Hegde P
FAU - Vani, Janakiraman
AU  - Vani J
FAU - Lacroix-Desmazes, Sebastien
AU  - Lacroix-Desmazes S
FAU - Bayry, Jagadeesh
AU  - Bayry J
FAU - Kaveri, Srini V
AU  - Kaveri SV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Autoimmune Diseases/immunology/therapy
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/therapy
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunologic Factors/*therapeutic use
MH  - Inflammation/immunology/therapy
MH  - Mice
MH  - Models, Immunological
MH  - T-Lymphocytes, Regulatory/*immunology/transplantation
EDAT- 2010/04/21 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1007/s10875-010-9394-5 [doi]
PST - ppublish
SO  - J Clin Immunol. 2010 May;30 Suppl 1:S4-8. doi: 10.1007/s10875-010-9394-5.