PMID- 20405270
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20211020
IS  - 1138-7548 (Print)
IS  - 1138-7548 (Linking)
VI  - 66
IP  - 1
DP  - 2010 Mar
TI  - Soluble HLA-G induces NF-kappaB activation in natural killer cells.
PG  - 39-46
LID - 10.1007/s13105-010-0005-y [doi]
AB  - Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for 
      the first time in the maternal-fetal interface. In cancer context, where high 
      number of natural killer (NK) cells is described, the presence of HLA-G in its 
      soluble form is thought to be essential for NK cells signaling. To evaluate 
      intracellular signaling in NK cells upon HLA-G soluble forms stimulation, we 
      investigate the role of soluble HLA-G (HLA-G5- and HLA-G1 shedding form) 
      stimulation on classical nuclear factor (NF)-kappaB pathway activation. We 
      reported that these two forms of soluble HLA-G could activate NF-kappaB in NK 
      cells. NF-kappaB activation in NK cells does implicate neither 
      phosphatidylinositol 3-kinase (PI3K) nor MEK (MAP kinase kinase) as demonstrated 
      after specific inhibition experiments. We demonstrated elsewhere that NF-kappaB 
      activation in NK cells is not implicated in cytotoxicity inhibition by HLA-G. Our 
      findings may suggest the important role played by NF-kappaB activation after 
      soluble HLA-G stimulation in other NK cells function.
FAU - Zidi, I
AU  - Zidi I
AD  - Commissariat a l'Energie Atomique, Service de Recherches en Hemato-Immunologie, 
      I2BM, Institut Universitaire d'Hematologie, Hopital Saint-Louis, 1 avenue Claude 
      Vellefaux, 75010 Paris, France. ines.zidi@techemail.com
FAU - Guillard, C
AU  - Guillard C
FAU - Carosella, E D
AU  - Carosella ED
FAU - Moreau, P
AU  - Moreau P
LA  - eng
PT  - Journal Article
DEP - 20100420
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (NF-kappa B)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Cell Line, Tumor
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Killer Cells, Natural/*metabolism
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - NF-kappa B/*metabolism
MH  - Phosphatidylinositol 3-Kinase/metabolism
MH  - Signal Transduction
MH  - Transfection
EDAT- 2010/04/21 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/04/21 06:00
PHST- 2009/06/13 00:00 [received]
PHST- 2009/09/24 00:00 [accepted]
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1007/s13105-010-0005-y [doi]
PST - ppublish
SO  - J Physiol Biochem. 2010 Mar;66(1):39-46. doi: 10.1007/s13105-010-0005-y. Epub 
      2010 Apr 20.