PMID- 20405273
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220409
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - Gastric emptying evaluation in children with erosive gastroesophageal reflux 
      disease.
PG  - 473-8
LID - 10.1007/s00383-010-2579-4 [doi]
AB  - BACKGROUND/AIMS: Delayed gastric emptying may be an important contributing factor 
      to gastroesophageal reflux disease (GERD) in children, but there are limited data 
      on its evaluation in children with erosive-GERD. This study aims to evaluate the 
      gastric emptying of a solid meal in patients with erosive-GERD. METHODS: Nineteen 
      patients (age range 8.79-17.9 years) with erosive esophagitis and 14 healthy 
      controls (age range from 8.04 to 18.7 years) were compared. Esophagitis was 
      graded according to Los Angeles classification. The gastric emptying was 
      evaluated by (13)C-octanoic breath test, which was performed after a 344 kcal 
      standardized solid test meal. Symptoms were evaluated using a standardized 
      questionnaire. RESULTS: The two most prevalent symptoms were nausea and 
      epigastric pain, which were reported by 12 (63.2%) patients. Irritable bowel 
      syndrome was present in 26.3% (5/19). The median gastric emptying half-time in 
      patients was 160 min (interquartile range [IQR] 140-174 min), which was not 
      different from the controls' figure (median 157 min, IQR 143-170 min). 
      Additionally, the lag time and the gastric emptying coefficient were not 
      significantly different between the study groups. CONCLUSION: Delayed gastric 
      emptying is not associated with erosive esophagitis in children with GERD, when 
      compared to controls.
FAU - Machado, Rodrigo Strehl
AU  - Machado RS
AD  - Pediatric Gasteroenterology Division, Department of Pediatrics, Escola Paulista 
      de Medicina da Universidade Federal de Sao Paulo, Rua Pedro de Toledo 441, Sao 
      Paulo, 04039-031, Brazil. rodrigo.strehl@unifesp.br
FAU - Yamamoto, Erica
AU  - Yamamoto E
FAU - da Silva Patricio, Francy Reis
AU  - da Silva Patricio FR
FAU - Reber, Marialice
AU  - Reber M
FAU - Kawakami, Elisabete
AU  - Kawakami E
LA  - eng
PT  - Journal Article
DEP - 20100221
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
SB  - IM
MH  - Adolescent
MH  - Breath Tests
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Child
MH  - Endoscopy, Digestive System
MH  - Female
MH  - *Gastric Emptying
MH  - Gastroesophageal Reflux/*physiopathology
MH  - Humans
MH  - Male
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
EDAT- 2010/04/21 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/02/02 00:00 [accepted]
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1007/s00383-010-2579-4 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2010 May;26(5):473-8. doi: 10.1007/s00383-010-2579-4. Epub 2010 
      Feb 21.