PMID- 20406304
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20211020
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 130
IP  - 4
DP  - 2010 Aug
TI  - Histamine-treated dendritic cells improve recruitment of type 2 CD8 T cells in 
      the lungs of allergic mice.
PG  - 589-96
LID - 10.1111/j.1365-2567.2010.03262.x [doi]
AB  - Histamine controls the function of dendritic cells (DCs). It appears to be 
      required for the normal development of DCs. It also induces the chemotaxis of 
      immature DCs and promotes the differentiation of CD4(+) T cells into cells with a 
      T helper type 2 (Th2) profile. Moreover, we have recently shown that histamine 
      stimulates both the uptake and the cross-presentation of antigens by DCs, 
      supporting the theory that histamine promotes activation of CD8(+) T cells during 
      the development of allergic pathologies. Here, we investigated whether the course 
      of an allergic response, in a well-defined model of ovalbumin (OVA)-induced 
      allergic airway inflammation, could be modulated by intratracheal injection of 
      OVA-pulsed DCs previously treated with histamine (DCHISs). Compared with control 
      DCs, DCHISs induced: (i) greater recruitment of CD8(+) T cells in the lung, (ii) 
      greater stimulation of the production of interleukin (IL)-5 by lung CD8(+) T 
      cells, and (iii) increased recruitment of CD11c/CD8 double-positive DCs in the 
      lungs of allergic mice. Moreover, mice treated with DCHISs showed increased 
      levels of serum-specific immunoglobulin E (IgE) antibodies directed to OVA, and a 
      higher proportion of eosinophils in bronchoalveolar lavage (BAL) compared with 
      mice treated with OVA-pulsed control DCs. Our results support the notion that 
      histamine, by acting on DCs, increases the severity of allergic processes.
FAU - Amaral, Maria M
AU  - Amaral MM
AD  - Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, 
      Argentina.
FAU - Alvarez, Carolina
AU  - Alvarez C
FAU - Langellotti, Cecilia
AU  - Langellotti C
FAU - Geffner, Jorge
AU  - Geffner J
FAU - Vermeulen, Monica
AU  - Vermeulen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100406
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Histamine/*immunology
MH  - Hypersensitivity/*immunology
MH  - Lung Diseases/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
PMC - PMC2913269
EDAT- 2010/04/22 06:00
MHDA- 2010/08/17 06:00
PMCR- 2011/08/01
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - IMM3262 [pii]
AID - 10.1111/j.1365-2567.2010.03262.x [doi]
PST - ppublish
SO  - Immunology. 2010 Aug;130(4):589-96. doi: 10.1111/j.1365-2567.2010.03262.x. Epub 
      2010 Apr 6.