PMID- 20406390
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20110615
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Jul
TI  - Paracoccidioidomycosis: a series of 66 patients with oral lesions from an endemic 
      area.
PG  - e189-95
LID - 10.1111/j.1439-0507.2010.01873.x [doi]
AB  - Paracoccidioidomycosis (PCM) is the most important systemic mycosis in Latin 
      America. It has been regarded as a multifocal disease, with oral lesions as the 
      prominent feature. To provide useful information concerning the diagnosis and 
      management of the disease, this study describes demographic and clinical data 
      from the medical records of a consecutive series of 66 Brazilian patients from an 
      endemic area, evaluated in a referral centre for oral diagnosis. In this sample 
      of patients, there was a predominance of middle-aged male patients, who were 
      primarily rural workers. Chronic multifocal disease was prevalent, with lesions 
      also detected in the lungs, lymph nodes, skin or adrenal glands. Most of the 
      cases presented with lesions at the gingival mucosa followed by the palate and 
      lips; these conditions occurring in the oral cavity were frequently associated 
      with pain. Importantly, most of the patients sought professional care for oral 
      lesions. The diagnosis was obtained through exfoliative cytology and/or biopsy of 
      the oral lesions. Medical treatment was effective, and there were no mortalities 
      in the sample. The present findings not only confirm the importance of oral 
      lesions in the diagnosis and management of PCM but also illustrate that questions 
      still remain unclear, such as the possibility of direct inoculation of the fungus 
      onto oral tissues.
CI  - (c) 2010 Blackwell Verlag GmbH.
FAU - Brazao-Silva, Marco Tullio
AU  - Brazao-Silva MT
AD  - Federal University of Triangulo Mineiro, Uberaba/MG, Brazil.
FAU - Andrade, Marilia Ferreira
AU  - Andrade MF
FAU - Franco, Talita
AU  - Franco T
FAU - Ribeiro, Rosy Iara Maciel Azambuja
AU  - Ribeiro RI
FAU - Silva, Weuler dos Santos
AU  - Silva Wdos S
FAU - Faria, Gabriele
AU  - Faria G
FAU - Faria, Paulo Rogerio de
AU  - Faria PR
FAU - Cardoso, Sergio Vitorino
AU  - Cardoso SV
FAU - Loyola, Adriano Mota
AU  - Loyola AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100406
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
SB  - IM
MH  - Adolescent
MH  - Adrenal Glands/pathology
MH  - Adult
MH  - Aged
MH  - Brazil/epidemiology
MH  - Child
MH  - *Endemic Diseases
MH  - Female
MH  - Gingiva/pathology
MH  - Humans
MH  - Lip/pathology
MH  - Lung/pathology
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Middle Aged
MH  - Palate/pathology
MH  - Paracoccidioides/*isolation & purification
MH  - Paracoccidioidomycosis/*diagnosis/*epidemiology/microbiology/pathology
MH  - Skin/pathology
MH  - Stomatitis/*diagnosis/*epidemiology/microbiology/pathology
MH  - Young Adult
EDAT- 2010/04/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - MYC1873 [pii]
AID - 10.1111/j.1439-0507.2010.01873.x [doi]
PST - ppublish
SO  - Mycoses. 2011 Jul;54(4):e189-95. doi: 10.1111/j.1439-0507.2010.01873.x. Epub 2010 
      Apr 6.