PMID- 20406482
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 36
DP  - 2010 Apr 20
TI  - Angiogenic biomarkers in children with congenital heart disease: possible 
      implications.
PG  - 32
LID - 10.1186/1824-7288-36-32 [doi]
AB  - BACKGROUND: Vascular endothelial growth factor (VEGF), platelet derived 
      endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) and leptin 
      are known as potent angiogenic factors The objective of the study was to evaluate 
      these angiogenic factors VEGF, PD-ECGF/TP and leptin in children with congenital 
      heart disease (CHD) and the factors that lead to angiogenesis in such cases. 
      METHODS: Sixty CHD children were studied and divided into two groups (n=30); 
      cyanotic-CHD (C-CHD) and acyanotic-CHD (A-CHD). Twenty five healthy children were 
      included as controls. RESULTS: Significantly higher serum levels of VEGF, 
      PD-ECGF/TP activity and leptin were detected in patients with CHD, particularly 
      in patients with C-CHD. CHD patients with SpO2<90%, pulmonary hypertension (PH), 
      severe pulmonary stenosis (PS), detectable collaterals, cardiomegaly and/or heart 
      failure showed significantly higher levels of these factors than those with 
      higher SpO2 or those without these findings. CONCLUSION: Hypoxia, PH and PS are 
      important factors that lead to harmful angiogenesis. However, angiogenesis could 
      be essential in some cases of CHD as coarctation of aorta to enhance renal 
      perfusion. This may provide new ways for therapeutic strategies aiming at 
      reducing or promoting angiogenesis in CHD to improve patient's outcome.
FAU - El-Melegy, Nagla T
AU  - El-Melegy NT
AD  - Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, 
      (71515), Egypt. elmelegynagla@yahoo.com
FAU - Mohamed, Nagwa A
AU  - Mohamed NA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100420
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.4.2.4 (Thymidine Phosphorylase)
SB  - IM
MH  - Biomarkers/*blood
MH  - Child, Preschool
MH  - Disease Progression
MH  - Echocardiography
MH  - Female
MH  - Heart Defects, Congenital/blood/*complications/diagnostic imaging
MH  - Humans
MH  - Leptin/blood
MH  - Male
MH  - Neovascularization, Pathologic/*blood/etiology
MH  - Prognosis
MH  - Spectrophotometry
MH  - Thymidine Phosphorylase/*blood
MH  - Vascular Endothelial Growth Factor A/*blood
PMC - PMC2874565
EDAT- 2010/04/22 06:00
MHDA- 2010/10/29 06:00
PMCR- 2010/04/20
CRDT- 2010/04/22 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
PHST- 2010/04/20 00:00 [pmc-release]
AID - 1824-7288-36-32 [pii]
AID - 10.1186/1824-7288-36-32 [doi]
PST - epublish
SO  - Ital J Pediatr. 2010 Apr 20;36:32. doi: 10.1186/1824-7288-36-32.