PMID- 20407859
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20211020
IS  - 1138-7548 (Print)
IS  - 1138-7548 (Linking)
VI  - 66
IP  - 1
DP  - 2010 Mar
TI  - Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune 
      responses to T-independent and T-dependent antigens.
PG  - 7-13
LID - 10.1007/s13105-010-0004-z [doi]
AB  - In rats, hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) 
      reduce humoral and cell-mediated immune responses. However, to our knowledge, the 
      differences in the effects of anterior versus posterior pituitary hormones on the 
      immune responses have not been studied to date. We compared in rats, the effects 
      of sham surgery (SHAM), HYPOX, and NIL on humoral immune responses to T 
      cell-independent (TI) type 1 antigen DNP-LPS and to TI type 2 antigen DNP-FICOLL, 
      as well as to T cell-dependent (TD) antigens ovalbumin (OVA) and bovine serum 
      albumin (BSA). The results showed that: (1) both HYPOX and NIL induced a similar 
      and significant decrease in IgM responses towards TI-1 antigens, (2) NIL but not 
      HYPOX induced a decreased IgM response to TI-2 antigens, and (3) both HYPOX and 
      NIL induced similar and significant decrease in IgG responses to TI-2 antigens. 
      Compared with the SHAM group, IgM responses to both TD antigens did not change in 
      HYPOX and NIL animals, whereas the IgG responses to OVA and BSA significantly 
      decreased in HYPOX and NIL animals. These results indicate that hormones of the 
      anterior and posterior pituitary play their own role in the regulation of humoral 
      immune responses.
FAU - Quintanar-Stephano, A
AU  - Quintanar-Stephano A
AD  - Departamento de Fisiologia y Farmacologia, Centro de Ciencias Basicas, 
      Universidad Autonoma de Aguascalientes, Aguascalientes, Mexico.
FAU - Abarca-Rojano, E
AU  - Abarca-Rojano E
FAU - Jarillo-Luna, R A
AU  - Jarillo-Luna RA
FAU - Rivera-Aguilar, V
AU  - Rivera-Aguilar V
FAU - Ventura-Juarez, J
AU  - Ventura-Juarez J
FAU - Berczi, I
AU  - Berczi I
FAU - Kovacs, K
AU  - Kovacs K
FAU - Campos-Rodriguez, R
AU  - Campos-Rodriguez R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
RN  - 0 (Antigens, T-Independent)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antigens, T-Independent/*immunology
MH  - Hypophysectomy
MH  - *Immunity, Humoral
MH  - Immunoglobulin G/immunology/metabolism
MH  - Immunoglobulin M/immunology/metabolism
MH  - Male
MH  - Ovalbumin/immunology
MH  - Pituitary Gland/*immunology/surgery
MH  - Rats
MH  - Serum Albumin, Bovine/immunology
MH  - T-Lymphocytes/*immunology
EDAT- 2010/04/22 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/06/04 00:00 [received]
PHST- 2009/08/04 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1007/s13105-010-0004-z [doi]
PST - ppublish
SO  - J Physiol Biochem. 2010 Mar;66(1):7-13. doi: 10.1007/s13105-010-0004-z. Epub 2010 
      Apr 21.