PMID- 20409333
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20221207
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 9
DP  - 2010 Apr 21
TI  - Pre-existing cardiovascular diseases and glycemic control in patients with type 2 
      diabetes mellitus in Europe: a matched cohort study.
PG  - 15
LID - 10.1186/1475-2840-9-15 [doi]
AB  - BACKGROUND: Although there is a growing body of evidence showing that patients 
      with type 2 diabetes mellitus (T2DM) have poor glycemic control in general, it is 
      not clear whether T2DM patients with pre-existing cardiovascular diseases (CVD) 
      are more or less likely to have good glycemic control than patients without 
      pre-existing CVD. Our aim was to examine the degree of glycemic control among 
      T2DM patients in Europe with and without pre-existing CVD. METHODS: This is a 
      matched cohort study based on a multi-center, observational study with 
      retrospective medical chart reviews of T2DM patients in Spain, France, United 
      Kingdom, Norway, Finland, Germany, and Poland. Included patients were aged >= 30 
      years at time of diagnosis of T2DM, had added a SU or a PPARgamma agonist to 
      failing metformin monotherapy (index date) and had pre-existing CVD (cases). A 
      control cohort with T2DM without pre-existing CVD was identified using 1:1 
      propensity score matching. With difference-in-difference approach, logistic and 
      linear regression analyses were applied to identify differences in glycemic 
      control by CVD during the follow up period, after controlling for baseline 
      demographics, clinical information, and concurrent anti-hyperglycemic medication 
      use. RESULTS: The percentage of case patients with adequate glycemic control 
      relative to control patients during the 1st, 2nd, 3rd, and 4th years after the 
      index date was 19.9 vs. 26.5, 16.8 vs. 26.5, 18.8 vs. 28.3, and 16.8 vs. 23.5 
      respectively. Cases were significantly less likely to have adequate glycemic 
      control (odds ratio: 0.62; 95% confidence interval: 0.46-0.82) than controls 
      after adjusting for baseline differences, secular trend, and other potential 
      confounding covariates. CONCLUSIONS: T2DM patients with pre-existing CVD tended 
      to have poorer glycemic control than those without pre-existing CVD, all other 
      factors being equal. It suggests that clinicians may need to pay more attention 
      to glycemic control among T2DM patients with CVD.
FAU - Fu, Alex Z
AU  - Fu AZ
AD  - Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, 
      USA. fuz@ccf.org
FAU - Qiu, Ying
AU  - Qiu Y
FAU - Radican, Larry
AU  - Radican L
FAU - Yin, Donald D
AU  - Yin DD
FAU - Mavros, Panagiotis
AU  - Mavros P
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (PPAR gamma)
RN  - 0 (Sulfonylurea Compounds)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*drug effects
MH  - Cardiovascular Diseases/*epidemiology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/epidemiology
MH  - Drug Therapy, Combination
MH  - Europe/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Metformin/therapeutic use
MH  - Middle Aged
MH  - Odds Ratio
MH  - PPAR gamma/agonists
MH  - Propensity Score
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sulfonylurea Compounds/therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC2876102
EDAT- 2010/04/23 06:00
MHDA- 2010/09/16 06:00
PMCR- 2010/04/21
CRDT- 2010/04/23 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/04/21 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
PHST- 2010/04/21 00:00 [pmc-release]
AID - 1475-2840-9-15 [pii]
AID - 10.1186/1475-2840-9-15 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2010 Apr 21;9:15. doi: 10.1186/1475-2840-9-15.