PMID- 20409730
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100906
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 52
IP  - 1-2
DP  - 2010 Oct-Nov
TI  - Mechanisms of mRNA translation of interferon stimulated genes.
PG  - 123-7
LID - 10.1016/j.cyto.2010.03.019 [doi]
AB  - Over the last two decades, a lot of research work has been focused on the 
      interferon (IFN)-regulated JAK-STAT pathway and understanding the mechanisms 
      governing the transcription of interferon stimulated genes (ISGs). Evidence 
      suggests that the JAK-STAT pathway alone does not account in its entirety for 
      mediating cellular responses to IFNs. There is emerging evidence that non-Stat 
      pathways play important roles in mediating signals for the generation of 
      IFN-responses. Various studies have underscored the importance of mitogen 
      activated protein kinases (MAPKs), especially p38 and ERK1/2, as well as the PI 
      3'K/AKT pathway in transmitting signals that are of critical importance for the 
      biological effects of IFNs. Besides regulating the transcription of ISGs in some 
      cases, engagement of these signaling pathways by the IFN-receptor (IFNR) 
      associated complexes also plays an important role in mediating the translation of 
      ISGs. The mechanisms regulating mRNA translation of ISGs is an area of ongoing 
      active research and a lot more efforts will be required to complete our 
      understanding of the various cellular elements involved in this process. In this 
      review we highlight the mechanisms regulating translation of ISGs. We focus on 
      the proteins regulated by the PI 3'K/AKT pathway, their role in mediating mRNA 
      translation of ISGs and the functional consequences of this regulation. In 
      addition, MAPKs are known to regulate the phosphorylation of various eukaryotic 
      initiation factors and we summarize the roles of eIF4B and eIF4E phosphorylations 
      on the translation of ISGs. The emerging roles of microRNAs in mRNA translation 
      of ISGs are also discussed.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Joshi, Sonali
AU  - Joshi S
AD  - Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, 
      Northwestern University Medical School, and Jesse Brown VA Medical Center, 
      Chicago, IL, USA.
FAU - Kaur, Surinder
AU  - Kaur S
FAU - Kroczynska, Barbara
AU  - Kroczynska B
FAU - Platanias, Leonidas C
AU  - Platanias LC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100420
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (Eukaryotic Initiation Factors)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (STAT Transcription Factors)
RN  - 0 (eIF-4B)
RN  - 9008-11-1 (Interferons)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Eukaryotic Initiation Factor-4E/metabolism
MH  - Eukaryotic Initiation Factors/metabolism
MH  - Humans
MH  - Interferon Regulatory Factors/*biosynthesis
MH  - Interferons/*metabolism
MH  - Janus Kinases/metabolism
MH  - MAP Kinase Signaling System/*physiology
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Peptide Chain Initiation, Translational/*physiology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphorylation/physiology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - STAT Transcription Factors/metabolism
EDAT- 2010/04/23 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/03/16 00:00 [received]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S1043-4666(10)00093-1 [pii]
AID - 10.1016/j.cyto.2010.03.019 [doi]
PST - ppublish
SO  - Cytokine. 2010 Oct-Nov;52(1-2):123-7. doi: 10.1016/j.cyto.2010.03.019. Epub 2010 
      Apr 20.