PMID- 20409850
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220409
IS  - 1933-1711 (Print)
IS  - 1878-7436 (Linking)
VI  - 1
IP  - 3
DP  - 2007 May-Jun
TI  - Chronic kidney disease and cardiovascular risk.
PG  - 178-84
LID - 10.1016/j.jash.2007.01.010 [doi]
AB  - Chronic kidney disease (CKD) is a global public health concern, and there is 
      emerging a strong relationship between CKD and increased cardiovascular disease 
      (CVD) risk. CKD in the presence of other co-morbidities such as type 2 diabetes 
      mellitus (T2DM) and hypertension (HTN) can lead to early progression to end-stage 
      renal disease (ESRD/stage V CKD) and confer a greater risk for CVD morbidity and 
      mortality. CVD events are the leading cause of premature death in patients with 
      CKD, even before their progression to ESRD, with the rate of CVD progression 
      being twice as common compared with the general population. The higher mortality 
      from CVD persists even after adjusting for most of the traditional risk factors, 
      suggesting the possible contributions of uremia-related, nontraditional risk 
      factors. This has led to the current understanding that the pathophysiology of 
      CVD in CKD involves a complex interplay of both the traditional as well as 
      nontraditional, uremia-related risk factors. This review will elaborate on the 
      pathophysiology of CVD in CKD and will discuss the role of microalbuminuria 
      (MAU)-proteinuria as a potential diagnostic and prognostic tool for CVD in CKD 
      risk assessment.
FAU - Yerram, Preethi
AU  - Yerram P
AD  - Department of Internal Medicine, University of Missouri School of Medicine, 
      Columbia, Missouri, USA.
FAU - Karuparthi, Poorna R
AU  - Karuparthi PR
FAU - Hesemann, Laura
AU  - Hesemann L
FAU - Horst, Jennifer
AU  - Horst J
FAU - Whaley-Connell, Adam
AU  - Whaley-Connell A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Soc Hypertens
JT  - Journal of the American Society of Hypertension : JASH
JID - 101312518
EDAT- 2007/05/01 00:00
MHDA- 2007/05/01 00:01
CRDT- 2010/04/23 06:00
PHST- 2006/12/09 00:00 [received]
PHST- 2007/01/26 00:00 [revised]
PHST- 2007/01/30 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2007/05/01 00:00 [pubmed]
PHST- 2007/05/01 00:01 [medline]
AID - S1933-1711(07)00040-X [pii]
AID - 10.1016/j.jash.2007.01.010 [doi]
PST - ppublish
SO  - J Am Soc Hypertens. 2007 May-Jun;1(3):178-84. doi: 10.1016/j.jash.2007.01.010.