PMID- 20412436
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20161018
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jul-Aug
TI  - Cardiac troponin I in Doberman Pinschers with cardiomyopathy.
PG  - 843-9
LID - 10.1111/j.1939-1676.2010.0516.x [doi]
AB  - BACKGROUND: Cardiac troponin I (cTnI) is useful for detection of cardiac myocyte 
      damage, but its efficacy in detecting various stages of dilated cardiomyopathy 
      (DCM) in Doberman Pinschers is unclear. OBJECTIVES: To evaluate the diagnostic 
      value of cTnI in various stages of DCM in Dobermans. ANIMALS: Six hundred and 
      fifty-three cTnI measurements of 336 Doberman Pinschers. METHODS: Using a 
      longitudinal study design, staging of the disease was based upon 
      24-hour-ambulatory-ECG (Holter) and echocardiography. A total of 447 cTnI 
      measurements were performed in 264 healthy Dobermans, and 206 cTnI measurements 
      in 75 Dobermans with cardiomyopathy. Eighty-eight cTnI samples were from dogs 
      with >100 ventricular premature contractions (VPCs)/24 hour, but without 
      echocardiographic changes ("VPC group"). Additional 19 samples originated from 
      dogs with only echocardiographic changes ("ECHO group"), and 56 samples from dogs 
      with both VPCs and echocardiographic changes ("VPC plus ECHO group"). Twenty 
      samples were from dogs with clinical signs ("clinical group"). The group 
      "incipient" included 23 dogs, that were considered to be normal according to 
      Holter and echocardiography at the time of the exam, but that developed DCM 
      within 1.5 years. RESULTS: cTnI values of dogs in all disease groups, including 
      the "incipient" (0.30+/-0.20) and "VPC group" (0.36+/-0.34), were significantly 
      (P=.04, P<.001) higher than the control group (0.07+/-0.16). A cut-off value of 
      >0.22 ng/mL had a sensitivity of 79.5% and a specificity of 84.4% to detect all 
      forms of cardiomyopathy. CONCLUSIONS AND CLINICAL IMPORTANCE: cTnI measurement is 
      a valuable diagnostic test that can detect cardiomyopathy in dogs that are 
      otherwise clinically normal.
FAU - Wess, G
AU  - Wess G
AD  - Clinic of Small Animal Medicine, Statistical Consulting Unit, LMU University, 
      Munich, Germany. gwess@lmu.de
FAU - Simak, J
AU  - Simak J
FAU - Mahling, M
AU  - Mahling M
FAU - Hartmann, K
AU  - Hartmann K
LA  - eng
PT  - Journal Article
DEP - 20100416
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Troponin I)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Cardiomyopathy, Dilated/blood/diagnosis/*veterinary
MH  - Dog Diseases/*blood/diagnosis
MH  - Dogs
MH  - Female
MH  - Male
MH  - Troponin I/*blood
EDAT- 2010/04/24 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - JVIM516 [pii]
AID - 10.1111/j.1939-1676.2010.0516.x [doi]
PST - ppublish
SO  - J Vet Intern Med. 2010 Jul-Aug;24(4):843-9. doi: 10.1111/j.1939-1676.2010.0516.x. 
      Epub 2010 Apr 16.