PMID- 20412549
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20161020
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 39
IP  - 3
DP  - 2010 Sep
TI  - Serum concentrations of monocyte chemoattractant protein-1 in healthy and 
      critically ill dogs.
PG  - 302-5
LID - 10.1111/j.1939-165X.2010.00228.x [doi]
AB  - BACKGROUND: The chemokine monocyte chemoattractant protein-1 (MCP-1) is a primary 
      regulator of monocyte mobilization from bone marrow, and increased concentrations 
      of MCP-1 have been associated with sepsis and other inflammatory disorders in 
      critically ill people. The relationship between MCP-1 and disease in dogs has not 
      been evaluated previously. OBJECTIVE: The purpose of this study was to assess 
      serum concentrations of MCP-1 in healthy dogs, dogs in the postoperative period, 
      and critically ill dogs. We hypothesized that MCP-1 concentrations would be 
      significantly increased in critically ill dogs compared with postoperative or 
      healthy dogs. METHODS: Serum concentrations of MCP-1 were measured in 26 healthy 
      control dogs, 35 postoperative dogs, and 26 critically ill dogs. Critically ill 
      dogs were further subgrouped into dogs with sepsis, parvovirus gastroenteritis, 
      immune-mediated hemolytic anemia, and severe trauma (n=26). MCP-1 concentrations 
      were determined using a commercial canine MCP-1 ELISA. Associations between MCP-1 
      concentrations and disease status were evaluated statistically. RESULTS: MCP-1 
      concentration was significantly higher in critically ill dogs (median 578 pg/mL, 
      range 144.7-1723 pg/mL) compared with healthy dogs (median 144 pg/mL, range 
      4.2-266.8 pg/mL) and postoperative dogs (median 160 pg/mL, range 12.6-560.4 
      pg/mL) (P<.001). All subgroups of critically ill dogs had increased MCP-1 
      concentrations with the highest concentrations occurring in dogs with sepsis. 
      However, differences among the 4 subgroups were not statistically significant. 
      CONCLUSION: Critically ill dogs had markedly increased serum concentrations of 
      MCP-1 compared with postoperative and healthy dogs. These results indicate that 
      surgery alone is not sufficient to increase MCP-1 concentrations; thus, 
      measurement of MCP-1 may be useful in assessing disease severity in critically 
      ill dogs.
CI  - (c)2010 American Society for Veterinary Clinical Pathology.
FAU - Duffy, Amanda L
AU  - Duffy AL
AD  - Department of Clinical Sciences, Colorado State University, Fort Collins, CO 
      80523, USA.
FAU - Olea-Popelka, Francisco J
AU  - Olea-Popelka FJ
FAU - Eucher, James
AU  - Eucher J
FAU - Rice, Dahlia M
AU  - Rice DM
FAU - Dow, Steven W
AU  - Dow SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Anemia, Hemolytic/blood/veterinary
MH  - Animals
MH  - Chemokine CCL2/*blood
MH  - Dog Diseases/*blood
MH  - Dogs/*blood
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Female
MH  - Gastroenteritis/blood/veterinary
MH  - Inflammation/blood/veterinary
MH  - Male
MH  - Parvoviridae Infections/blood/veterinary
MH  - Postoperative Period
MH  - Sepsis/blood/veterinary
EDAT- 2010/04/24 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - VCP228 [pii]
AID - 10.1111/j.1939-165X.2010.00228.x [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2010 Sep;39(3):302-5. doi: 10.1111/j.1939-165X.2010.00228.x.