PMID- 20413021
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100423
IS  - 1558-0539 (Electronic)
IS  - 0733-8627 (Linking)
VI  - 28
IP  - 2
DP  - 2010 May
TI  - Immune reconstitution inflammatory syndrome.
PG  - 393-407, Table of Contents
LID - 10.1016/j.emc.2010.01.004 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) must be considered in the 
      differential diagnosis for any patient infected with HIV who has begun ART in the 
      preceding months. Distinguishing between manifestations of IRIS and active 
      infection is of paramount importance and poses a diagnostic challenge to the 
      provider in the acute care setting. Presentations of IRIS are often atypical for 
      the precipitating pathogen, and novel presentations are likely. Of the diseases 
      associated with IRIS, mycobacteria and cryptococcal infections are commonly 
      encountered, as are dermatologic symptoms in general. The most clinically 
      significant complications of IRIS are those involving the central nervous system, 
      lungs, and eye, and in many of these scenarios systemic steroids may be of 
      benefit. Management should rarely include interruption of ART, except possibly in 
      severe, life-threatening complications.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Beatty, George W
AU  - Beatty GW
AD  - Positive Health Program at San Francisco General Hospital, University of 
      California San Francisco, Building 80, Ward 84, 995 Potrero Avenue, San 
      Francisco, CA 94110, USA. gbeatty@php.ucsf.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Emerg Med Clin North Am
JT  - Emergency medicine clinics of North America
JID - 8219565
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications
MH  - Abdominal Pain/etiology
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active/adverse effects
MH  - Diagnosis, Differential
MH  - Emergency Medicine/methods
MH  - Emergency Treatment/*methods
MH  - Fever/etiology
MH  - Graves Disease/complications
MH  - HIV Infections/*complications/drug therapy/immunology
MH  - Headache/etiology
MH  - Hepatitis/etiology
MH  - Humans
MH  - *Immune Reconstitution Inflammatory 
      Syndrome/diagnosis/epidemiology/etiology/therapy
MH  - Incidence
MH  - Lung Diseases/etiology
MH  - Risk Factors
MH  - Sarcoidosis/complications
MH  - Skin Diseases/etiology
EDAT- 2010/04/24 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S0733-8627(10)00005-2 [pii]
AID - 10.1016/j.emc.2010.01.004 [doi]
PST - ppublish
SO  - Emerg Med Clin North Am. 2010 May;28(2):393-407, Table of Contents. doi: 
      10.1016/j.emc.2010.01.004.