PMID- 20413033
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220330
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 55
IP  - 17
DP  - 2010 Apr 27
TI  - Continuous flow left ventricular assist device improves functional capacity and 
      quality of life of advanced heart failure patients.
PG  - 1826-34
LID - 10.1016/j.jacc.2009.12.052 [doi]
AB  - OBJECTIVES: This study sought to assess the impact of continuous flow left 
      ventricular assist devices (LVADs) on functional capacity and heart 
      failure-related quality of life. BACKGROUND: Newer continuous-flow LVAD are 
      smaller and quieter than pulsatile-flow LVADs. METHODS: Data from advanced heart 
      failure patients enrolled in the HeartMate II LVAD (Thoratec Corporation, 
      Pleasanton, California) bridge to transplantation (BTT) (n = 281) and destination 
      therapy (DT) (n = 374) trials were analyzed. Functional status (New York Heart 
      Association [NYHA] functional class, 6-min walk distance, patient activity 
      scores), and quality of life (Minnesota Living With Heart Failure [MLWHF] and 
      Kansas City Cardiomyopathy Questionnaires [KCCQ]) were collected before and after 
      LVAD implantation. RESULTS: Compared with baseline, LVAD patients demonstrated 
      early and sustained improvements in functional status and quality of life. Most 
      patients had NYHA functional class IV symptoms at baseline. Following implant, 
      82% (BTT) and 80% (DT) of patients at 6 months and 79% (DT) at 24 months improved 
      to NYHA functional class I or II. Mean 6-min walk distance in DT patients was 204 
      m in patients able to ambulate at baseline, which improved to 350 and 360 m at 6 
      and 24 months. There were also significant and sustained improvements from 
      baseline in both BTT and DT patients in median MLWHF scores (by 40 and 42 U in DT 
      patients, or 52% and 55%, at 6 and 24 months, respectively), and KCCQ overall 
      summary scores (by 39 and 41 U, or 170% and 178%). CONCLUSIONS: Use of a 
      continuous flow LVAD in advanced heart failure patients results in clinically 
      relevant improvements in functional capacity and heart failure-related quality of 
      life.
CI  - Copyright (c) 2010 American College of Cardiology Foundation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Rogers, Joseph G
AU  - Rogers JG
AD  - Duke University Medical Center, Durham, NC 27710, USA. joseph.rogers@duke.edu
FAU - Aaronson, Keith D
AU  - Aaronson KD
FAU - Boyle, Andrew J
AU  - Boyle AJ
FAU - Russell, Stuart D
AU  - Russell SD
FAU - Milano, Carmelo A
AU  - Milano CA
FAU - Pagani, Francis D
AU  - Pagani FD
FAU - Edwards, Brooks S
AU  - Edwards BS
FAU - Park, Soon
AU  - Park S
FAU - John, Ranjit
AU  - John R
FAU - Conte, John V
AU  - Conte JV
FAU - Farrar, David J
AU  - Farrar DJ
FAU - Slaughter, Mark S
AU  - Slaughter MS
CN  - HeartMate II Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
CIN - J Am Coll Cardiol. 2010 Apr 27;55(17):1835-6. PMID: 20413034
CIN - Nat Rev Cardiol. 2010 Jul;7(7):360. PMID: 20590000
MH  - Equipment Design
MH  - Female
MH  - Heart Failure/physiopathology/*therapy
MH  - Heart Ventricles
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - Walking/physiology
EDAT- 2010/04/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/09/06 00:00 [received]
PHST- 2009/12/18 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - S0735-1097(10)01022-3 [pii]
AID - 10.1016/j.jacc.2009.12.052 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2010 Apr 27;55(17):1826-34. doi: 10.1016/j.jacc.2009.12.052.