PMID- 20413700
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20181201
IS  - 1941-2452 (Electronic)
IS  - 0884-5336 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Apr
TI  - Testing for food reactions: the good, the bad, and the ugly.
PG  - 192-8
LID - 10.1177/0884533610362696 [doi]
AB  - An increasing number of commercial tests for food allergies are marketed to 
      consumers and healthcare practitioners with tenuous claims. The aim of this 
      article is to provide an evidence-based review of the tests and procedures that 
      currently are used for patients with suspected food allergy. A systematic review 
      of the literature evaluating the validity of tests and procedures used in food 
      reactions was performed using conventional search engines (eg, PubMed, Ovid) as 
      well as consumer sites (eg, Google, Bing). The National Library of Medicine 
      Medical Subject Headings (MeSH) term food hypersensitivity was used along with 
      food allergy testing, food sensitivity testing, food intolerance testing, and 
      adverse food reactions. Of the results obtained, testing for immunoglobulin E 
      (IgE)-mediated food allergy was best represented in PubMed. IgE-based testing 
      continues to be the gold standard for suspected food allergies. Among modalities 
      used by many conventional and alternative practitioners, immunoglobulin G 
      (IgG)-based testing showed promise, with clinically meaningful results. It has 
      been proven useful as a guide for elimination diets, with clinical impact for a 
      variety of diseases. Mediator release testing and antigen leukocyte cellular 
      antibody testing were only represented on consumer sites. Further investigation 
      into the validity and the clinical application of these tests and procedures is 
      required. Disclosing the basis for food reactions continues to present a 
      diagnostic challenge, and testing for food allergies in the context of an 
      appropriate clinical history is paramount to making the correct diagnosis.
FAU - Mullin, Gerard E
AU  - Mullin GE
AD  - Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 
      gmullin1@jhmi.edu
FAU - Swift, Kathie M
AU  - Swift KM
FAU - Lipski, Liz
AU  - Lipski L
FAU - Turnbull, Laura K
AU  - Turnbull LK
FAU - Rampertab, S Devi
AU  - Rampertab SD
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Nutr Clin Pract
JT  - Nutrition in clinical practice : official publication of the American Society for 
      Parenteral and Enteral Nutrition
JID - 8606733
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Evidence-Based Medicine
MH  - Food Hypersensitivity/blood/*diagnosis/immunology
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Immunoglobulin G/blood/*immunology
MH  - *Skin Tests
RF  - 27
EDAT- 2010/04/24 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 25/2/192 [pii]
AID - 10.1177/0884533610362696 [doi]
PST - ppublish
SO  - Nutr Clin Pract. 2010 Apr;25(2):192-8. doi: 10.1177/0884533610362696.